Evaluating Immune Responses to Dengue and Sepsis in Hospitalized Patients in Cambodia
Status: Recruiting
Location: See all (3) locations...
Study Type: Observational
SUMMARY
The goal of this research study is to help the investigators better understand serious dengue disease. The investigators will collect clinical information and up to four blood samples from participants with dengue, sepsis, or healthy people. The investigators will perform multiple analyses on the blood samples and compare results between dengue patients and those with sepsis and healthy people.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 2
Healthy Volunteers: t
View:
• Patients with dengue-like illness:
⁃ Patients presenting with dengue-like symptoms for a duration of maximum 72h before inclusion. Dengue-like symptoms include: presentation with oral temperature \>38°C AND at least two of the following symptoms suggestive of dengue-like illness: headache, retro-orbital pain, myalgia, joint pain, rash, any bleeding symptoms, nausea or vomiting, lethargy or restlessness , abdominal pain, liver enlargement
• Sepsis patients:
⁃ Patients admitted for less than 48 hours with a primary diagnosis of sepsis as per treating team AND have blood cultures ordered AND on empiric antibiotics due to concern for bacterial infection.
• Healthy controls:
⁃ Participants with no chronic illness, no regular medications, no febrile illness in 28 days, no diagnosis of or treatment for dengue or bacterial infection in the past 6 months.
Locations
Other Locations
Cambodia
Kampong Speu District Referral Hospital
RECRUITING
Kampong Speu
International Center of Excellence in Research Cambodia
RECRUITING
Phnom Penh
Preah Kossamak Hospital
RECRUITING
Phnom Penh
Contact Information
Primary
Chanthap Lon, MD
lonc@icercambodia.org
+855 12976 799
Backup
Camila D Odio, MD
camila.odio@nih.gov
Time Frame
Start Date:2025-06-02
Estimated Completion Date:2026-12
Participants
Target number of participants:240
Treatments
Healthy controls
Participants with no chronic illness, no regular medications, no febrile illness in 28 days, no diagnosis of or treatment for dengue or bacterial infection in the past 6 months.
Patients with dengue-like illness
Patients presenting with dengue-like symptoms for a duration of maximum 72h before inclusion. Dengue-like symptoms include: presentation with oral temperature \>38°C AND at least two of the following symptoms suggestive of dengue-like illness: headache, retro-orbital pain, myalgia, joint pain, rash, any bleeding symptoms, nausea or vomiting, lethargy or restlessness, abdominal pain, liver enlargement.
Sepsis patients
Patients admitted for less than 48 hours with a primary diagnosis of sepsis as per treating team AND have blood cultures ordered AND on empiric antibiotics due to concern for bacterial infection.