Denys-Drash Syndrome (DDS) Overview
Learn About Denys-Drash Syndrome (DDS)
Denys-Drash syndrome is a condition that affects the kidneys and genitalia.
Mutations in the WT1 gene cause Denys-Drash syndrome. The WT1 gene provides instructions for making a protein that regulates the activity of other genes by attaching (binding) to specific regions of DNA. On the basis of this action, the WT1 protein is called a transcription factor. The WT1 protein plays a role in the development of the kidneys and gonads (ovaries in females and testes in males) before birth.
The prevalence of Denys-Drash syndrome is unknown; at least 150 affected individuals have been reported in the scientific literature.
This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder.
Huntsville Renal Clinic, PC
Saad Rahman is a Nephrologist in Fayetteville, Tennessee. Dr. Rahman and is rated as an Advanced provider by MediFind in the treatment of Denys-Drash Syndrome (DDS). His top areas of expertise are End-Stage Renal Disease (ESRD), Chronic Kidney Disease, Acute Kidney Failure, and High Potassium Level. Dr. Rahman is currently accepting new patients.
Vanderbilt University Medical Center
Scott Borinstein is a Pediatric Hematologist Oncology specialist and a Hematologist in Nashville, Tennessee. Dr. Borinstein and is rated as an Advanced provider by MediFind in the treatment of Denys-Drash Syndrome (DDS). His top areas of expertise are Osteosarcoma, Ewing Sarcoma, Adult Soft Tissue Sarcoma, Rhabdomyosarcoma, and Bone Marrow Aspiration. Dr. Borinstein is currently accepting new patients.
Vanderbilt University Medical Center
Tracy Hunley is a Pediatric Nephrologist and a Nephrologist in Nashville, Tennessee. Dr. Hunley and is rated as an Experienced provider by MediFind in the treatment of Denys-Drash Syndrome (DDS). His top areas of expertise are Nephrotic Syndrome, Focal Segmental Glomerulosclerosis, Nephrocalcinosis, Hypophosphatemia, and Gastrostomy. Dr. Hunley is currently accepting new patients.
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Published Date: March 01, 2013
Published By: National Institutes of Health