Denys-Drash Syndrome (DDS)Symptoms, Doctors, Treatments, Advances & More
Learn About Denys-Drash Syndrome (DDS)
Denys-Drash syndrome is a condition that affects the kidneys and genitalia.
Mutations in the WT1 gene cause Denys-Drash syndrome. The WT1 gene provides instructions for making a protein that regulates the activity of other genes by attaching (binding) to specific regions of DNA. On the basis of this action, the WT1 protein is called a transcription factor. The WT1 protein plays a role in the development of the kidneys and gonads (ovaries in females and testes in males) before birth.
The prevalence of Denys-Drash syndrome is unknown; at least 150 affected individuals have been reported in the scientific literature.
This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder.
Atrium Health Levine Children’s Cancer & Blood Disorders, A Facility Of Carolinas Medical Center
Joel Kaplan is a Hematologist and a Pediatrics provider practicing medicine in Charlotte, North Carolina. He has been practicing medicine for over 25 years. Dr. Kaplan is rated as an Advanced provider by MediFind in the treatment of Denys-Drash Syndrome (DDS). He is also highly rated in 15 other conditions, according to our data. His clinical expertise encompasses Neuroblastoma, Embryonal Tumor with Multilayered Rosettes, Medulloblastoma, Langerhans Cell Histiocytosis, and Bone Marrow Aspiration. Dr. Kaplan is board certified in American Board Of Pediatrics and American Board Of Pediatrics, Pediatric Hematology And Oncology. Dr. Kaplan is currently accepting new patients.
Sorahia Domenice practices practicing medicine in Sao Paulo, Brazil. Domenice is rated as an Elite expert by MediFind in the treatment of Denys-Drash Syndrome (DDS). They are also highly rated in 12 other conditions, according to our data. Their clinical expertise encompasses Intersex, Partial Androgen Insensitivity Syndrome (PAIS), Denys-Drash Syndrome (DDS), Turner Syndrome, and Hormone Replacement Therapy (HRT).
BHMA Hospitalists- Lonesome Pine Hospital Norton Campus
Adedoyin Akintide is a Hospital Medicine provider practicing medicine in Norton, Virginia. Dr. Akintide is rated as an Advanced provider by MediFind in the treatment of Denys-Drash Syndrome (DDS). He is also highly rated in 8 other conditions, according to our data. His clinical expertise encompasses Nephrosclerosis, Renovascular Hypertension, Chronic Kidney Disease, Ureteroscopy, and Endoscopy. Dr. Akintide is board certified in American Board Of Internal Medicine.
Summary: The phase I portion of this study is designed for children or adolescents and young adults (AYA) with a diagnosis of a solid tumor that has recurred (come back after treatment) or is refractory (never completely went away). The trial will test 2 combinations of therapy and participants will be randomly assigned to either Arm A or Arm B. The purpose of the phase I study is to determine the highest ...
Summary: This phase II trial studies how well combination chemotherapy works in treating patients with newly diagnosed stage II-IV diffuse anaplastic Wilms tumors (DAWT) or favorable histology Wilms tumors (FHWT) that have come back (relapsed). Drugs used in chemotherapy regimens such as UH-3 (vincristine, doxorubicin, cyclophosphamide, carboplatin, etoposide, and irinotecan) and ICE/Cyclo/Topo (ifosfamide...
Published Date: March 01, 2013
Published By: National Institutes of Health