Denys-Drash Syndrome (DDS)Symptoms, Doctors, Treatments, Advances & More
Learn About Denys-Drash Syndrome (DDS)
Denys-Drash syndrome is a condition that affects the kidneys and genitalia.
Mutations in the WT1 gene cause Denys-Drash syndrome. The WT1 gene provides instructions for making a protein that regulates the activity of other genes by attaching (binding) to specific regions of DNA. On the basis of this action, the WT1 protein is called a transcription factor. The WT1 protein plays a role in the development of the kidneys and gonads (ovaries in females and testes in males) before birth.
The prevalence of Denys-Drash syndrome is unknown; at least 150 affected individuals have been reported in the scientific literature.
This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder.
Atrium Health Levine Children’s Cancer & Blood Disorders, A Facility Of Carolinas Medical Center
Joel Kaplan is a Hematologist and a Pediatrics provider practicing medicine in Charlotte, North Carolina. He has been practicing medicine for over 25 years. Dr. Kaplan is rated as an Advanced provider by MediFind in the treatment of Denys-Drash Syndrome (DDS). He is also highly rated in 15 other conditions, according to our data. His clinical expertise encompasses Neuroblastoma, Embryonal Tumor with Multilayered Rosettes, Medulloblastoma, Langerhans Cell Histiocytosis, and Bone Marrow Aspiration. Dr. Kaplan is board certified in American Board Of Pediatrics and American Board Of Pediatrics, Pediatric Hematology And Oncology. Dr. Kaplan is currently accepting new patients.
Sorahia Domenice practices practicing medicine in Sao Paulo, Brazil. Domenice is rated as an Elite expert by MediFind in the treatment of Denys-Drash Syndrome (DDS). They are also highly rated in 12 other conditions, according to our data. Their clinical expertise encompasses Intersex, Partial Androgen Insensitivity Syndrome (PAIS), Denys-Drash Syndrome (DDS), Turner Syndrome, and Hormone Replacement Therapy (HRT).
Regional Kidney Care
. Dr. Butler is rated as an Advanced provider by MediFind in the treatment of Denys-Drash Syndrome (DDS). He is also highly rated in 18 other conditions, according to our data. His clinical expertise encompasses End-Stage Renal Disease (ESRD), Chronic Kidney Disease, Acute Kidney Failure, and Nephrosclerosis. Dr. Butler is board certified in American Board Of Internal Medicine.
Summary: Patients may be considered if the cancer has come back, has not gone away after standard treatment or the patient cannot receive standard treatment. This research study uses special immune system cells called CARE T cells, a new experimental treatment. The body has different ways of fighting infection and disease. No single way seems perfect for fighting cancers. This research study combines two d...
Summary: The study is based on results form 2 previous studies carried out by the GFAOP. The aim of this study is to evaluate the capacity of units to follow the recommendations in the protocol.
Published Date: March 01, 2013
Published By: National Institutes of Health