PANTHER Study: Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Drug
Study Type: Observational
SUMMARY
Early diabetic kidney disease (DKD) occurs in 50-70% of youth with type 2 diabetes (T2D) and confers high lifetime risk of dialysis and premature death. Youth-onset T2D typically manifests during or shortly after puberty in adolescents with obesity. Epidemiological data implicate puberty as an accelerator of kidney disease in youth with obesity and diabetes and the investigators posit that the link between puberty and T2D-onset may explain the high burden of DKD in youth-onset T2D. A better understanding of the impact of puberty on kidney health is needed to promote preservation of native kidney function, especially in youth with T2D.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 8
Maximum Age: 14
Healthy Volunteers: t
View:
• HbA1c ≥6.0% for untreated high-risk group
• BMI ≥ 85th %ile for high-risk group
• Normal HbA1c ≤5.6% for control group
• Type 1 diabetes (T1D) Antibody negative
Locations
United States
Colorado
Children's Hospital Colorado
RECRUITING
Aurora
Washington
Seattle Children's Hospital
RECRUITING
Seattle
Contact Information
Primary
Petter Bjornstad, MD
pettermb@uw.edu
(206) 616 3543
Time Frame
Start Date:2021-09-27
Estimated Completion Date:2027-12-01
Participants
Target number of participants:100
Treatments
Youth with overweight/obesity and/or newly diagnosed T2D and elevated HbA1c
All participants will undergo GFR (Iohexol Inj 300 MG/ML), EPRF (Aminohippurate Sodium Inj 20%), Dextran sieving (Dextran 40 Sodium Inj 0.9%), IVGTT for insulin sensitivity, in addition to BOLD and ASL Kidney MRI
Healthy normal-weight controls
All participants will undergo GFR (Iohexol Inj 300 MG/ML), EPRF (Aminohippurate Sodium Inj 20%), Dextran sieving (Dextran 40 Sodium Inj 0.9%), IVGTT for insulin sensitivity, in addition to BOLD and ASL Kidney MRI