• Age range from 18 to 75 years;

• ECOG performance status: 0-2;

• Histopathologically confirmed untreated diffuse large B-cell lymphoma (cell origin can be distinguished according to Hans algorithm) , And fulfilled the following criteria for high-risk CNS recurrence:

∙ CNS-IPI 4-6;

‣ The lymphoma involved testis, breast (excluding unilateral breast and less than 5 cm mass), adrenal gland, kidney, paranasal sinus, paravertebral, and bone marrow and other sites;

‣ PCLBCL-leg;

• Subjects have at least one measurable lesion: the long axis of the lymph node shall be\>1.5 cm, the long axis of the extranodal lesions shall be\>1.0 cm;

• Bone marrow hematopoiesis was essentially normal: WBC≥3.5 ×10\^9/L, ANC≥1.5×10\^9/L, PLT≥80×10\^9/L, Hb≥90 g/L. Abnormal peripheral blood indices, as a result of lymphoma invading the bone marrow or spleen, permitted enrollment at the discretion of the investigator;

• Liver function: total bilirubin, ALT, AST \< 1.5×UNL (upper limit of normal);

• Renal function: Cr \< 1.5×UNL and creatinine clearance≥30 ml/min;

• Echocardiography or nuclide cardiac function testing with LVEF≥50%;

• Patients in the reproductive period agreed to appropriate contraception. Women in the reproductive period had a negative serum pregnancy test within 2 weeks before enrollment;

⁃ Consent to provide pathological tissue specimens (wax blocks within half a year or 20 slides for paraffin tissue sections);

⁃ Life expectancy≥3 months;

⁃ Signed informed consent;