Defining the Genetics, Biomarkers and Outcomes for Dilated Cardiomyopathy: a Prospective Multi-centre Observational Study

Status: Recruiting
Location: See all (6) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY

Finding new ways to diagnose and treat Dilated Cardiomyopathy (DCM) could improve the health and well-being of patients with this condition. The main aim of this research study is to help develop better ways of diagnosing and treating patients with DCM. The information that is collected may help develop tailored treatments for patients with this disease in the future. This research study will recruit patients with DCM from a number of centres across England and follow their health over a period of years. Patients will give some blood samples for a type of genetic test called whole genome sequencing (WGS) to look for genetic changes. Patients will also have a magnetic resonance imaging (MRI) scan of their heart to look for any changes in the heart such as scarring, and check their heart function. The aim of this study is to discover if using WGS and MRI can improve the diagnosis of DCM. Another aim of the study is to look at how genetic changes and scarring in the heart may affect the progress of the disease. Studying patients with DCM may also help the investigators learn more about diagnosing and treating other diseases of the heart. The second aim of this study is to see whether using WGS and MRI scanning can also be useful in other types of heart diseases which might be affected by genetic changes or scarring in the heart.

Eligibility
Participation Requirements
Sex: All
Maximum Age: 99
Healthy Volunteers: f
View:

• Male or female participants of any age

• Capacity to provide informed consent

• Patients with a confirmed diagnosis of DCM

• Affected family members of patients meeting diagnostic criteria for DCM

• Males or females of any age

• Capacity to provide informed consent

• Patients with hypokinetic non-dilated cardiomyopathy, or

• Family members of DCM patients with possible or probable DCM or

• Patients with a confirmed diagnosis of heritable cardiovascular disease or

• Family members of patients with heritable cardiovascular disease, both affected and unaffected

Locations
Other Locations
United Kingdom
Leeds Teaching Hospitals NHS Trust
RECRUITING
Leeds
Glenfield Hospital
RECRUITING
Leicester
Liverpool Heart and Chest Hospital NHS Foundation Trust
RECRUITING
Liverpool
Royal Brompton & Harefield NHS Foundation Trust
RECRUITING
London
Oxford University Hospitals NHS Foundation Trust
RECRUITING
Oxford
Southampton General Hospital
NOT_YET_RECRUITING
Southampton
Contact Information
Primary
James Ware
go-dcm@imperial.ac.uk
0330 128 2294
Backup
Chief Investigator
go-dcm@imperial.ac.uk
0330 128 2294
Time Frame
Start Date: 2020-01-09
Estimated Completion Date: 2027-07-22
Participants
Target number of participants: 2000
Treatments
Part 1: Dilated Cardiomyopathy patients
Approximately 1200 patients recruited prospectively from participating sites with a diagnosis of Dilated Cardiomyopathy (DCM). Will also include approximately 800 retrospective patients diagnosed with DCM currently biobanked by the lead site.
Part 2: Heritable Cardiovascular Disease
Patients may be recruited with other diagnosed heritable cardiovascular disorders. Family members of patients may be invited to take part in the study. Children may also be approached to take part in the study.
Sponsors
Collaborators: Royal Brompton & Harefield NHS Foundation Trust, British Heart Foundation
Leads: Imperial College London

This content was sourced from clinicaltrials.gov