Donovanosis (granuloma inguinale) is a sexually transmitted disease that is rarely seen in the United States.
Granuloma inguinale; Sexually transmitted disease - donovanosis; STD - donovanosis; Sexually transmitted infection - donovanosis; STI - donovanosis
Donovanosis (granuloma inguinale) is caused by the bacterium Klebsiella granulomatis. The disease is commonly found in tropical and subtropical areas such as southeast India, Guyana, and New Guinea. There are about 100 cases reported per year in the United States. Most of these cases occur in people who have traveled to or are from places where the disease is common.
The disease spreads mostly through vaginal or anal intercourse. Very rarely, it spreads during oral sex.
Most infections occur in people ages 20 to 40.
Symptoms can occur 1 to 12 weeks after coming in contact with the disease causing bacteria.
These may include:
In its early stages, it may be hard to tell the difference between donovanosis and chancroid.
In the later stages, donovanosis may look like advanced genital cancers, lymphogranuloma venereum, and anogenital cutaneous amebiasis.
Antibiotics are used to treat donovanosis. These may include azithromycin, doxycycline, ciprofloxacin, erythromycin, and trimethoprim-sulfamethoxazole. To cure the condition, long-term treatment is needed. Most treatment courses run 3 weeks or until the sores have completely healed.
A follow-up examination is important because the disease can reappear after it seems to be cured.
Treating this disease early decreases the chances of tissue damage or scarring. Untreated disease leads to damage of the genital tissue.
Health problems that may result from this disease include:
Call for an appointment with your health care provider if:
Avoiding all sexual activity is the only absolute way to prevent a sexually transmitted disease such as donovanosis. However, safer sex behaviors may reduce your risk.
The proper use of condoms, either the male or female type, greatly decreases the risk of catching a sexually transmitted disease. You need to wear the condom from the beginning to the end of each sexual activity.
Gardella C, Eckert LO, Lentz GM. Genital tract infections: vulva, vagina, cervix, toxic shock syndrome, endometritis, and salpingitis. In: Lobo RA, Gershenson DM, Lentz GM, Valea FA, eds. Comprehensive Gynecology. 7th ed. Philadelphia, PA: Elsevier Saunders; 2017:chap 23.
Ghanem KG, Hook EW. Granuloma inguinale (Donovanosis). In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier Saunders; 2020:chap 300.
Stoner BP, Reno HEL. Klebsiella granulomatis (donovanosis, granuloma inguinale). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier Saunders; 2020:chap 235.
There is no recent research available for this condition. Please check back because thousands of new papers are published every week and we strive to find and display the most recent relevant research as soon as it is available.
There are no recent clinical trials available for this condition. Please check back because new trials are being conducted frequently.