Learn About Double Discordia

What is the definition of Double Discordia?
Double discordia, also known as atrio-ventricular and ventriculo-arterial double discordia, is a rare congenital disorder of the heart and great arteries in which the right atrium is connected to the left ventricle and the left atrium is connected to the right ventricle. The great arteries may be transposed, and the ventricles of the heart are also inverted.
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What are the symptoms of Double Discordia?
Symptoms of double discordia may include cyanosis (bluish skin and lip color), tachycardia (rapid heartbeat), hepatomegaly (enlarged liver), tachypnoea (rapid breathing), heart murmur, diaphoresis (excessive sweating), failure to thrive syndrome, tricuspid valve regurgitation, congestive heart failure, and impaired ventricular function.
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What are the current treatments for Double Discordia?
Treatment for double discordia may include cardiac surgery to correct the congenital defects and the drugs, tadalafil and phosphodiesterase inhibitors.
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What are the latest Double Discordia Clinical Trials?
Cardiac Resynchronization Therapy in Adult Congenital Heart Disease With Systemic Right Ventricle: A Cross-Over Trial

Summary: The main objective of RIGHT-CRT is to assess the impact/efficacy of CRT on functional capacity in ACHD patients with SRV.

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Percutaneous Edge To Edge Repair for the Treatment of Severe Tricuspid Valve Regurgitation in High-surgical Risk Patients With Systemic Right Ventricle : a Multicentric French Cohort.

Summary: Our study is about to follow adult congenital patients, known with systemic right ventricle (mostly correct transposition of the great arteries ou congenitally corrected transposition fo the great arteries) and systemic valve severe regurgitation which was treated with a Mitraclip device on this tricuspid valve. It's an observationnal study with a 2 years follow up with clinical (symptoms, complic...

What are the Latest Advances for Double Discordia?
Contemporary outcomes of the double switch operation for congenitally corrected transposition of the great arteries.
Heartmate 3 as a bridge to heart transplantation in a patient with congenitally corrected transposition of the great arteries: a case report.
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