Dravet Syndrome Overview

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Learn About Dravet Syndrome

What is the definition of Dravet Syndrome?
Dravet syndrome is the most severe of a group of conditions known as SCN1A-related seizure disorders. Symptoms include seizures which first occur in infancy that are often triggered by high temperatures (febrile seizures). In childhood, many types of seizures may occur and they may increase in frequency. Seizures may be difficult to treat. Other symptoms include loss of motor skills, intellectual disability, speech impairment, and difficulty with movement. Most cases of Dravet syndrome occur when the SCN1A gene is not working correctly. It can be inherited in an autosomal dominant pattern, but most people with Dravet syndrome do not have a family history of the condition. Diagnosis is based on a clinical exam, medical history, and the results of genetic testing.
What are the alternative names for Dravet Syndrome?
  • Dravet syndrome
  • Myoclonic epilepsy, severe, of infancy
  • SME
  • SMEI
  • Severe Myoclonic Epilepsy of Infancy
Who are the top Dravet Syndrome Local Doctors?
Dr. Paul C. Miller
Neurology
Dr. Paul C. Miller
Neurology

Bone And Joint Institute Of Tennessee Inc

3000 Edward Curd Ln, 
Franklin, TN 
 (2.7 mi)
615-791-2360
Languages Spoken:
English
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Accepting New Patients
Offers Telehealth

Paul Miller is a Neurologist in Franklin, Tennessee. Dr. Miller and is rated as a Distinguished provider by MediFind in the treatment of Dravet Syndrome. His top areas of expertise are Memory Loss, Seizures, Dravet Syndrome, and Tension Headache. Dr. Miller is currently accepting new patients.

Dr. Martin J. Gallagher
Neurology | Psychiatry
Dr. Martin J. Gallagher
Neurology | Psychiatry

Vanderbilt University Medical Center

2105 Edward Curd Lane, 
Franklin, TN 
 (2.8 mi)
615-794-8700
Languages Spoken:
English, Spanish
See accepted insurances
Accepting New Patients
Offers Telehealth

Martin Gallagher is a Neurologist and a Psychiatrist in Franklin, Tennessee. Dr. Gallagher and is rated as an Advanced provider by MediFind in the treatment of Dravet Syndrome. His top areas of expertise are Epilepsy Juvenile Absence, Seizures, Epilepsy, and Juvenile Myoclonic Epilepsy. Dr. Gallagher is currently accepting new patients.

 
 
 
 
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Dr. Kevin F. Haas
Neurology | Nephrology
Dr. Kevin F. Haas
Neurology | Nephrology

Vanderbilt University Medical Center

2107 Edward Curd Lane, 
Franklin, TN 
 (2.8 mi)
615-591-9890
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Kevin Haas is a Neurologist and a Nephrologist in Franklin, Tennessee. Dr. Haas and is rated as an Advanced provider by MediFind in the treatment of Dravet Syndrome. His top areas of expertise are Seizures, Epilepsy, Generalized Tonic-Clonic Seizure, and Memory Loss. Dr. Haas is currently accepting new patients.

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What are the latest Dravet Syndrome Clinical Trials?
Open-Label, Single-Arm, Phase 3 Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Fenfluramine (Hydrochloride) in Infants 1 Year to Less Than 2 Years of Age With Dravet Syndrome
Open-Label, Single-Arm, Phase 3 Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Fenfluramine (Hydrochloride) in Infants 1 Year to Less Than 2 Years of Age With Dravet Syndrome
Enrollment Status: Recruiting
Publish Date: February 12, 2025
Intervention Type: Drug
Study Phase: Phase 3

Summary: The primary purpose of this study is evaluate the safety and tolerability of fenfluramine hydrochloride (HCl) 0.2 to 0.8 mg/kg/day in infants 1 year to less than 2 years of age with Dravet syndrome.

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A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Investigate the Efficacy, Safety, and Tolerability of LP352 in the Treatment of Seizures in Children and Adults with Dravet Syndrome
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Investigate the Efficacy, Safety, and Tolerability of LP352 in the Treatment of Seizures in Children and Adults with Dravet Syndrome
Enrollment Status: Recruiting
Publish Date: February 11, 2025
Intervention Type: Drug
Study Phase: Phase 3

Summary: This (DEEp SEA Study) is a double-blind, randomized, placebo-controlled, multicenter study to investigate the efficacy, safety, and tolerability of LP352 in the treatment of seizures in children and adults with DS. The study consists of 3 main phases: Screening, Titration period, and Maintenance period, followed by a Taper period and Follow-Up. Participants will be randomized to LP352 or placebo. ...

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center