Cortical Silent Period in Laryngeal Dystonia
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY
The goal of this observational study is to evaluate the cortical silent period (cSP) in cricothyroid muscle (CT) in laryngeal dystonia and control healthy subjects. The study will provide norms related to latency and amplitude of motor evoked potentials (MEPs) and duration of cSP in CT muscle in laryngeal dystonia and control healthy subjects. Findings may give a baseline in comparison to findings in laryngeal diseases and insight into maladaptive cortical control function during phonation in laryngeal diseases like laryngeal dystonia.
Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: t
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• adults (18-65 years old), no implanted metals in the body (e.g. pacemaker, metal prosthesis in the skull and oral cavity).
Locations
Other Locations
Croatia
University of Split School of Medicine
RECRUITING
Split
Contact Information
Primary
Maja Rogić Vidaković, PhD
maja.rogic@mefst.hr
+385098508210
Time Frame
Start Date: 2022-10-10
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 20
Treatments
Laryngeal Dystonia
The study will be performed on 10-15 (maximal 20) subjects with diagnosed laryngeal dystonia who meet the exclusion/ inclusion criteria.~Inclusion criteria: adults (18-65 years old) who have confirmed diagnosis of laryngeal dystonia, no implanted metals in body (e.g. pacemaker, metal prosthesis in skull and oral cavity).~Exclusion criteria: pregnancy, other neurological disorders, psychiatric disorders, epilepsy or history of previous epilepsy attack, using of brain affecting pharmaceuticals, traumatic, tumor, infectious, metabolic brain lesions, heart conditions (15 ).~The composition of the group is represented is both gender, various age gap, and different height.~Before the beginning of testing, all subjects with a confirmed diagnosis of laryngeal dystonia will be once again evaluated by a specialist otorhinolaryngologist at the University Hospital of Split. Medical documentation of the examination will be available for further analysis.
Healthy subjects
The study will be performed on 20 healthy volunteering subjects who meet the exclusion/ inclusion criteria.~Inclusion criteria: healthy adults (18-65 years old), no implanted metals in body (e.g. pacemaker, metal prosthesis in the skull and oral cavity) Exclusion criteria: pregnancy, neurological disorders, psychiatric disorders, epilepsy or history of previous epilepsy attack, using of the brain affecting pharmaceuticals, traumatic, tumor, infectious, metabolic brain lesions, heart conditions.~The composition of the group is represented is both gender, various age gap, and different height.
Related Therapeutic Areas
Sponsors
Collaborators: University Hospital of Split
Leads: University of Split, School of Medicine