Effects of Combined Transcranial Electrical and Magnetic Stimulation of Cerebellum on Balance Function in Ataxia Patients

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Ataxia refers to a group of neurological disorders characterized by impaired coordination and balance due to dysfunction in the cerebellum or its connections. Traditional therapeutic approaches for ataxia have shown limited efficacy, prompting researchers to explore alternative interventions. Non-invasive brain stimulation (NIBS) techniques, such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), and intermittent theta burst stimulation (iTBS), have emerged as potential therapeutic options. The aim of this study is to investigate the combined effect of tACS-iTBS on balance functions in ataxia disorders.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 8
Maximum Age: 80
Healthy Volunteers: f
View:

• Confirmed diagnosis of ataxia based on clinical assessment and/or neuroimaging findings.

• Stable medication regimen for at least four weeks prior to the study.

• Sufficient cognitive ability to understand and comply with study instructions.

Locations
Other Locations
Italy
IRCCS Santa Lucia Foundation
RECRUITING
Rome
Contact Information
Primary
Giacomo Koch, Prof.
g.koch@hsantalucia.it
0651501181
Backup
Valentina Pezzopane, MSc
v.pezzopane@hsantalucia.it
0651501181
Time Frame
Start Date: 2025-05-01
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 30
Treatments
Experimental: Real tACS + real iTBS + exergaming
10 sessions of real 5Hz tACS with real iTBS + exergaming biofeedback, 5 times per weeks for two weeks.
Placebo_comparator: Sham tACS + sham iTBS + exergaming
10 sessions of sham 5Hz tACS with sham iTBS + exergaming biofeedback, 5 times per weeks for two weeks.
Related Therapeutic Areas
Sponsors
Leads: I.R.C.C.S. Fondazione Santa Lucia

This content was sourced from clinicaltrials.gov