Dubin-Johnson syndrome is a condition characterized by jaundice, which is a yellowing of the skin and whites of the eyes. In most affected people jaundice appears during adolescence or early adulthood. Jaundice is typically the only feature of Dubin-Johnson syndrome, but some people can experience weakness, mild abdominal pain, nausea, or vomiting. In most people with Dubin-Johnson syndrome, certain deposits build up in the liver but do not seem to impair liver function. The deposits make the liver appear black when viewed with medical imaging.
Dubin-Johnson syndrome is caused by changes in a gene known as ABCC2. The ABCC2 gene provides instructions for making a protein that transports certain substances out of cells so they can be released (excreted) from the body. For example, this protein transports a substance called bilirubin out of liver cells and into bile (a digestive fluid produced by the liver). Bilirubin is produced during the breakdown of old red blood cells and has an orange-yellow tint.
The prevalence of Dubin-Johnson syndrome is unknown. It appears to be most common in Iranian and Moroccan Jews living in Israel, with 1 in 1,300 individuals affected. Additionally, several people in the Japanese population have been diagnosed with Dubin-Johnson syndrome. This condition appears to be less common in other populations.
This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.
Takao Togawa practices in Nagoya, Japan. Togawa is rated as an Elite expert by MediFind in the treatment of Dubin-Johnson Syndrome. He is also highly rated in 11 other conditions, according to our data. His top areas of expertise are Dubin-Johnson Syndrome, Rotor Syndrome, Cholestasis, and Progressive Familial Intrahepatic Cholestasis Type 1.
Suresh Chari is a Gastroenterologist in Houston, Texas. Chari has been practicing medicine for over 42 years and is rated as a Distinguished expert by MediFind in the treatment of Dubin-Johnson Syndrome. He is also highly rated in 14 other conditions, according to our data. His top areas of expertise are Hereditary Pancreatitis, Pancreatic Cancer, Chronic Pancreatitis, Endoscopy, and Stent Placement. He is licensed to treat patients in Texas, Minnesota, and Arizona. Chari is currently accepting new patients.
Veronique Barbu practices in Paris, France. Barbu is rated as a Distinguished expert by MediFind in the treatment of Dubin-Johnson Syndrome. She is also highly rated in 9 other conditions, according to our data. Her top areas of expertise are Gallstones, Dubin-Johnson Syndrome, Intrahepatic Cholestasis of Pregnancy, Rotor Syndrome, and Gallbladder Removal.
Summary: Autoimmune pancreatitis (AIP) is a special type of chronic pancreatitis mediated by autoimmunity. The classic manifestation of AIP is diffuse pancreatic enlargement, some of which are characterized by focal enlargement. Clinically, it is divided into diffuse AIP (DAIP) and focal AIP (FAIP) according to morphology. FAIP can be clinically manifested as obstructive jaundice, peripancreatic lymphadeno...
Published Date: August 01, 2018Published By: National Institutes of Health