A Prospective Clinical Trial of Radiation Therapy for Dupuytren's Contracture Following Surgical and Non-Surgical Release
The goal of this study is to learn about preventing recurrence of Dupuytren's Contracture. The main question it aims to answer are: • Does targeted radiation therapy decrease recurrence of Dupuytren's contracture after treatment with Collagenase Clostridium Histolyticum? Participants will undergo: * Release of Dupuytren's Contracture after Collagenase Clostridium Histolyticum injection * Daily radiation therapy treatment for 5 days followed by 6-8 week rest period and then another course of 5 days of radiation therapy
• Age 45 or greater with DC
• Extension deficit \>10 degrees
• Unable to simultaneously place the affected finger and palm flat on a table.
• Women included in the study will be post-menopausal or using contraception, and a pregnancy test will be performed as standard of care.
• For patients who are having multiple CCH injections, only the first 2 joints on given hand will be included