Learn About Dupuytren Contracture
Dupuytren contracture is characterized by a deformity of the hand in which the joints of one or more fingers cannot be fully straightened (extended); their mobility is limited to a range of bent (flexed) positions. The condition is a disorder of connective tissue, which supports the body's muscles, joints, organs, and skin and provides strength and flexibility to structures throughout the body. In particular, Dupuytren contracture results from shortening and thickening of connective tissues in the hand, including fat and bands of fibrous tissue called fascia; the skin is also involved.
While the cause of Dupuytren contracture is unknown, changes in one or more genes are thought to affect the risk of developing this disorder. Some of the genes associated with the disorder are involved in a biological process called the Wnt signaling pathway. This pathway promotes the growth and division (proliferation) of cells and is involved in determining the specialized functions a cell will have (differentiation).
Dupuytren contracture occurs in about 5 percent of people in the United States. The condition is 3 to 10 times more common in people of European descent than in those of non-European descent.
Dupuytren contracture is usually passed down through generations in families and is the most common inherited disorder of connective tissue. The inheritance pattern is often unclear. Some people who inherit gene changes associated with Dupuytren contracture never develop the condition.
Tidewater Orthopaedic Associates Inc.
Robert Campolattaro is a Hand Surgeon and an Orthopedics provider in Hampton, Virginia. Dr. Campolattaro is rated as a Distinguished provider by MediFind in the treatment of Dupuytren Contracture. His top areas of expertise are Rhizarthrosis, Dupuytren Contracture, Ganglion Cyst, Carpal Tunnel Syndrome, and Fasciotomy. Dr. Campolattaro is currently accepting new patients.
Brigham And Womens Physicians Organization Inc
Philip Blazar is a Hand Surgeon in Boston, Massachusetts. Dr. Blazar is rated as an Elite provider by MediFind in the treatment of Dupuytren Contracture. His top areas of expertise are Dupuytren Contracture, Carpal Tunnel Syndrome, Rhizarthrosis, Fasciotomy, and Nerve Decompression. Dr. Blazar is currently accepting new patients.
Clayton Peimer is a Hand Surgeon and an Orthopedics provider in Marquette, Michigan. Dr. Peimer is rated as an Elite provider by MediFind in the treatment of Dupuytren Contracture. His top areas of expertise are Dupuytren Contracture, Carpal Tunnel Syndrome, Rhizarthrosis, and Ganglion Cyst.
Summary: To determine if the clinical impression of clinicians, ie that patients are improving with the current treatment pathway for Dupuytren's (contracture release followed by radiation), can be substantiated with scientific evidence.
Summary: Dupuytren's disease is a frequent hereditary disease in Northern Europe. It is a degenerative disease affecting the palmar aponeurosis of the hand. It develops a progressive contractile fibrosis which cuts the hypodermic fatty tissue, adheres to the skin and the phalanges, gradually bending the affected rays, resulting in significant functional impotence. Various medical and surgical treatments ar...
Published Date: April 01, 2019
Published By: National Institutes of Health