Safety and Efficacy of Endobronchial Valve for Bronchoscopic Lung Volume Reduction Surgery: a Prospective Pilot Study
The goal of this pliot study al is to preliminarily evaluate the effectiveness and safety of transbronchial lung volume reduction surgery using the self-devloped endobronchial valves for chronic obstructive pulmonary disease patients with emphysema phenotype . The main questions it aims to answer are: Does self-devloped endobronchial valves improve the lung function、exercise capacity and symptons of participants? What surgery-related adverse events do participants have after transbronchial lung volume reduction surgery using the self-devloped endobronchial valves? Participants will: undergo transbronchial lung volume reduction surgery using the self-devloped endobronchial valves. receive follow-up before surgery (baseline) and 3 days, 4 weeks, 12weeks after surgery.
• 1\. Patients with chronic obstructive pulmonary disease based on GOLD diagnostic criteria;
• 2\. Age range from 40 to 85 years old (including 40 and 85 years old);
• 3\. BMI ≤ 35kg/m2;
• 4\. 15% ≤ FEV1% pred ≤ 45%;
• 5\. TLC\>100% pred, RV\>140% pred, and DLCO/red% ≥ 20%;
• 6\. 100m ≤ 6WMD ≤ 500m after rehabilitation training;
• 7\. Quit smoking for more than 4 months;
• 8\. The evaluation result of pulmonary bypass ventilation function is negative;
• 9\. Participants in this clinical trial requires the signing of an informed consent form by the individual or legal representative.