Evolution of Positron Emission Computed Tomography (PET) Fixation With Fluorodeoxyglucose (FDG) at the End of Antibiotic Treatment of Infective Endocarditis on Valvular Prosthesis

Status: Recruiting
Location: See location...
Intervention Type: Radiation
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

In patients with prosthetic valve endocarditis (PVE) and pathological valvular FDG uptake on the initial FDG-PET and not referred to valve replacement at the acute phase, the study will assess whether FDG-PET is able to identify those at increased risk of PVE relapse.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patient aged 18 or over;

• Have a prosthetic valve implanted surgically or by catheter for at least 3 months;

• Presenting a definite IE on a prosthetic valve (ESC definition in force);

• Having benefited from an FDG-PET examination for diagnostic purposes as part of the treatment revealing pathological hyperuptake at the level of the prosthetic valve AND carried out \<15 days after the start of antibiotic therapy for infective endocarditis;

• Absence of cardiac surgical intervention performed for the current episode of AE or planned before the end-of-treatment FDG-PET

Locations
Other Locations
France
Hôpital Bichat-Claude Bernard
RECRUITING
Paris
Contact Information
Primary
François Rouzet, MD, PHD
francois.rouzet@aphp.fr
01.40.25.64.11
Backup
Xavier Duval, MD, PHD
xavier.duval@aphp.fr
Time Frame
Start Date: 2025-04-17
Estimated Completion Date: 2027-12
Participants
Target number of participants: 50
Treatments
Experimental: Definite prosthetic valve endocarditis
adult patients with a valvular prosthesis presenting a definite infective endocarditis (IE) according to the ESC classification in force, not operated on in the acute phase (before the PET scan at the end of treatment) and presenting a pathological FDG uptake on the prosthetic valve at the start of curative antibiotic treatment.
Related Therapeutic Areas
Sponsors
Leads: Assistance Publique - Hôpitaux de Paris

This content was sourced from clinicaltrials.gov