Discovering New Targets for Hereditary and Sporadic Colorectal and Endometrial Cancer Risk Reduction

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

The primary aim of this study is to collect and store data, tissue, and personal and family histories from patients being screened for colorectal cancer and/or endometrial cancer at NYPH and WCM for routine clinical care and to make these available for future use for molecular and mechanistic studies.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
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∙ The following eligibility criteria must be met as follows:

• Age ≥ 18 years old.

• One of the following must be met:

‣ Diagnosis of a Hereditary Cancer Syndrome by positive genetic testing and/or clinical criteria to undergo an endoscopy procedure (esophagoduodenoscopy and/or colonoscopy/flexible sigmoidoscopy), or endometrial screening procedure (transvaginal ultrasound and/or hysteroscopy and/or endometrial biopsy), OR

⁃ Individuals coming to Weill-Cornell Medicine/NYPH to undergo an endoscopy procedure, transvaginal ultrasound, or hysteroscopy for average-risk (population-based) recommendation OR

⁃ Individuals diagnosed with colorectal cancer or endometrial cancer coming to Weill- Cornell Medicine/NYPH for surgical treatment OR

⁃ Individuals coming to Weill-Cornell Medicine/NYPH for care such as, but not limited to, diagnostic testing, clinic and/or treatment visit.

• Willingness and ability to sign informed consent.

• Ability to read/understand English, Spanish, and/or simplified Chinese.

Locations
United States
New York
NYP/Weill Cornell Medicine
RECRUITING
New York
Contact Information
Primary
Steven M Lipkin, MD, PhD
stl2012@med.cornell.edu
212-746-4014
Backup
Melissa K Frey, MD, MS
mkf2002@med.cornell.edu
646-697-6621
Time Frame
Start Date: 2019-05-29
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 1120
Treatments
FAP without treatment with NSAIDs
Patients with the Hereditary Cancer Syndrome known as Familial Adenomatous Polyposis (FAP) undergoing upper or lower endoscopy/surgery without treatment with NSAIDs
FAP on treatment with NSAIDs
Patients with the Hereditary Cancer Syndrome known as Familial Adenomatous Polyposis (FAP) undergoing upper or lower endoscopy/surgery on treatment with NSAIDs
HNPCC without treatment with NSAIDs
Patients with the Hereditary Cancer Syndrome known as Hereditary Non-Polyposis Colorectal Cancer (HNPCC) undergoing lower endoscopy/surgery without treatment with NSAIDs
HNPCC on treatment with NSAIDs
Patients with the Hereditary Cancer Syndrome known as Hereditary Non-Polyposis Colorectal Cancer (HNPCC) undergoing lower endoscopy/surgery on treatment with NSAIDs
Other Hereditary Colorectal Cancer Syndromes
Other Hereditary Colorectal Cancer Syndromes undergoing lower endoscopy/surgery
Average-risk population
Average-risk population undergoing lower endoscopy/surgery in the lower gastrointestinal tract.
Sponsors
Leads: Weill Medical College of Cornell University
Collaborators: National Cancer Institute (NCI)

This content was sourced from clinicaltrials.gov