Familial Colorectal Cancer
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Familial Colorectal Cancer Overview

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Learn About Familial Colorectal Cancer

What is the definition of Familial Colorectal Cancer?
Familial colon cancer is a cluster of colon cancer within a family. Most cases of colon cancer occur sporadically in people with little to no family history of the condition. Approximately 3-5% of colon cancer is considered "hereditary" and is thought to be caused by an inherited predisposition to colon cancer that is passed down through a family in an autosomal dominant or autosomal recessive manner. In some of these families, the underlying genetic cause is not known; however, many of these cases are caused by changes in the APC, MYH, MLH1, MSH2, MSH6, PMS2, EPCAM, PTEN, STK11, SMAD4, BMPR1A, NTHL1, POLE, and POLD1 genes (which are associated with hereditary cancer syndromes). An additional 10-30% of people diagnosed with colon cancer have a significant family history of the condition but have no identifiable genetic change in a gene known to cause a hereditary predisposition to colon cancer. These clusters of colon cancer are likely due to a combination of gene(s) and other shared factors such as environment and lifestyle.
What are the alternative names for Familial Colorectal Cancer?
  • Familial colorectal cancer
  • Colorectal cancer, familial
Who are the top Familial Colorectal Cancer Local Doctors?
Elite in Familial Colorectal Cancer
Elite in Familial Colorectal Cancer
Referral may be required

City Of Hope Comprehensive Cancer Center-Duarte

1500 Duarte Rd, 
Duarte, CA 
888-304-3959
Languages Spoken:
English
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Offers Telehealth

Marwan Fakih is an Oncologist practicing medicine in Duarte, California. Dr. Fakih is rated as an Elite provider by MediFind in the treatment of Familial Colorectal Cancer. He is also highly rated in 18 other conditions, according to our data. His clinical expertise encompasses Colorectal Cancer, Squamous Cell Carcinoma of the Anal Canal (SCAC), Anal Cancer, Liver Embolization, and Endoscopy.

Distinguished in Familial Colorectal Cancer
Dr. John M. Sayles
General Surgery | Colorectal Surgery
Distinguished in Familial Colorectal Cancer
Dr. John M. Sayles
General Surgery | Colorectal Surgery
Referral required
Before you request

Sentara Surgery Specialists

6251 E. Virginia Beach Blvd., Suite 300, 
Norfolk, VA 
757-261-5000
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

John Sayles is a General Surgeon and a Colorectal Surgeon practicing medicine in Norfolk, Virginia. Dr. Sayles is rated as a Distinguished provider by MediFind in the treatment of Familial Colorectal Cancer. He is also highly rated in 24 other conditions, according to our data. His clinical expertise encompasses Familial Colorectal Cancer, Squamous Cell Carcinoma of the Anal Canal (SCAC), Anal Cancer, Hernia Surgery, and Ileostomy. Dr. Sayles is board certified in American Board Of Surgery - Surgery (General Surgery) - 2028 and American Board Of Colon & Rectal Surgery - Colon & Rectal Surgery - 2029. Dr. Sayles is currently accepting new patients.

 
 
 
 
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Distinguished in Familial Colorectal Cancer
Dr. Carlos G. Miranda
General Surgery | Colorectal Surgery
Distinguished in Familial Colorectal Cancer
Dr. Carlos G. Miranda
General Surgery | Colorectal Surgery
Referral may be required
Before you request

Sentara Surgery Specialists

2790 Godwin Blvd, Suite 305, 
Suffolk, VA 
757-934-4222
Languages Spoken:
English
See accepted insurances
Accepting New Patients

Carlos Miranda is a General Surgeon and a Colorectal Surgeon practicing medicine in Suffolk, Virginia. Dr. Miranda is rated as a Distinguished provider by MediFind in the treatment of Familial Colorectal Cancer. He is also highly rated in 23 other conditions, according to our data. His clinical expertise encompasses Familial Colorectal Cancer, Diverticular Disease, Retroperitoneal Inflammation, Hernia Surgery, and Gallbladder Removal. Dr. Miranda is board certified in American Board Of Colon & Rectal Surgery - Colon & Rectal Surgery - 2029 and American Board Of Surgery - Surgery (General Surgery) - 2027. Dr. Miranda is currently accepting new patients.

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What are the latest Familial Colorectal Cancer Clinical Trials?
Evaluation of Provider vs. Patient Mediated Cascade Genetic Testing of First-Degree Relatives of Patients With Newly Diagnosed Colorectal Cancer
Evaluation of Provider vs. Patient Mediated Cascade Genetic Testing of First-Degree Relatives of Patients With Newly Diagnosed Colorectal Cancer
Enrollment Status: Recruiting
Publish Date: September 02, 2026
Intervention Type: Other, Procedure
Study Phase: Not Applicable

Summary: This clinical trial compares patient (proband)-mediated communication to provider-mediated communication for improving genetic testing in first-degree relatives of patients with newly diagnosed colorectal cancer. It is estimated that 30% of cases of colorectal cancer have a genetic basis and about 15% of these patients have a disease-causing (pathogenic) inherited (germline) variant in a cancer su...

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Phase 2 Study to Evaluate the Efficacy and Safety of TPST-1495 in Patients With Familial Adenomatous Polyposis (FAP)
Phase 2 Study to Evaluate the Efficacy and Safety of TPST-1495 in Patients With Familial Adenomatous Polyposis (FAP)
Enrollment Status: Recruiting
Publish Date: September 01, 2026
Intervention Type: Drug, Procedure, Other
Study Phase: Phase 2

Summary: This open-label phase II trial tests how well TPST-1495 works in reducing the number of polyps in the small bowel and colon in patients with familial adenomatous polyposis (FAP). FAP is an inherited condition in which numerous polyps (growths that protrude from mucous membranes) form on the inside walls of the colon and rectum. It increases the risk for colon cancer. TPST-1495 binds to specific pr...

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center