Familial Colorectal Cancer
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Familial Colorectal Cancer Overview

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Learn About Familial Colorectal Cancer

What is the definition of Familial Colorectal Cancer?
Familial colon cancer is a cluster of colon cancer within a family. Most cases of colon cancer occur sporadically in people with little to no family history of the condition. Approximately 3-5% of colon cancer is considered "hereditary" and is thought to be caused by an inherited predisposition to colon cancer that is passed down through a family in an autosomal dominant or autosomal recessive manner. In some of these families, the underlying genetic cause is not known; however, many of these cases are caused by changes in the APC, MYH, MLH1, MSH2, MSH6, PMS2, EPCAM, PTEN, STK11, SMAD4, BMPR1A, NTHL1, POLE, and POLD1 genes (which are associated with hereditary cancer syndromes). An additional 10-30% of people diagnosed with colon cancer have a significant family history of the condition but have no identifiable genetic change in a gene known to cause a hereditary predisposition to colon cancer. These clusters of colon cancer are likely due to a combination of gene(s) and other shared factors such as environment and lifestyle.
What are the alternative names for Familial Colorectal Cancer?
  • Familial colorectal cancer
  • Colorectal cancer, familial
Who are the top Familial Colorectal Cancer Local Doctors?
Distinguished in Familial Colorectal Cancer
Dr. Edward S. James
Hematology | Oncology
Distinguished in Familial Colorectal Cancer
Dr. Edward S. James
Hematology | Oncology

Advocate Lutheran General Cancer Institute

1700 Luther Ln 1st & 2nd Fl, 
Park Ridge, IL 
847-268-8200
Languages Spoken:
English
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Offers Telehealth

Edward James is a Hematologist and an Oncologist practicing medicine in Park Ridge, Illinois. Dr. James is rated as a Distinguished provider by MediFind in the treatment of Familial Colorectal Cancer. He is also highly rated in 14 other conditions, according to our data. His clinical expertise encompasses Familial Colorectal Cancer, Colorectal Cancer, Pancreatic Cancer, Familial Pancreatic Cancer, and Gastrostomy. Dr. James is board certified in American Board Of Internal Medicine, Medical Oncology.

Distinguished in Familial Colorectal Cancer
Dr. Thomas D. Weyburn
Hematology | Oncology
Distinguished in Familial Colorectal Cancer
Dr. Thomas D. Weyburn
Hematology | Oncology

Advocate Infusion Center

525 E Congress Pkwy, Ste 300, 
Crystal Lake, IL 
815-759-9260
Languages Spoken:
English
See accepted insurances
Offers Telehealth

Thomas Weyburn is a Hematologist and an Oncologist practicing medicine in Crystal Lake, Illinois. Dr. Weyburn is rated as a Distinguished provider by MediFind in the treatment of Familial Colorectal Cancer. He is also highly rated in 36 other conditions, according to our data. His clinical expertise encompasses Pleuropulmonary Blastoma, Lung Cancer, Small Cell Lung Cancer (SCLC), and Familial Colorectal Cancer. Dr. Weyburn is board certified in American Board Of Internal Medicine, Hematology.

 
 
 
 
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Distinguished in Familial Colorectal Cancer
Dr. Ibrahim N. Nakhoul
Oncology
Distinguished in Familial Colorectal Cancer
Dr. Ibrahim N. Nakhoul
Oncology

Ballad Health Cancer Center

2202 North John B. Dennis Highway, Suite 100, 
Kingsport, TN 
423-578-8500
Languages Spoken:
English
See accepted insurances
Offers Telehealth

. Dr. Nakhoul is rated as a Distinguished provider by MediFind in the treatment of Familial Colorectal Cancer. He is also highly rated in 32 other conditions, according to our data. His clinical expertise encompasses Colorectal Cancer, Lung Cancer, Familial Colorectal Cancer, and Pleuropulmonary Blastoma. Dr. Nakhoul is board certified in American Board Of Internal Medicine.

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What are the latest Familial Colorectal Cancer Clinical Trials?
The Impact of Functional Status and Respiratory Parameters on Long-Term Outcomes in Colorectal Cancer
The Impact of Functional Status and Respiratory Parameters on Long-Term Outcomes in Colorectal Cancer
Enrollment Status: Recruiting
Publish Date: April 13, 2026

Summary: Colorectal cancer is one of the most commonly diagnosed malignancies worldwide and a leading cause of cancer-related morbidity and mortality. Its global incidence continues to increase, with a substantial proportion of cases diagnosed at advanced stages, which adversely affects prognosis. Patients diagnosed at an early stage and treated with surgery have significantly better long-term survival out...

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Phase I Trial of ZEN003694 (ZEN-3694) in Combination With Capecitabine in Patients With Solid Tumors
Phase I Trial of ZEN003694 (ZEN-3694) in Combination With Capecitabine in Patients With Solid Tumors
Enrollment Status: Recruiting
Publish Date: April 13, 2026
Intervention Type: Procedure, Drug
Study Phase: Phase 1

Summary: This phase I trial tests the safety, side effects, and best dose of ZEN003694 in combination with the usual treatment with capecitabine in treating patients with cancer that has spread from where it first started (primary site) to other places in the body (metastatic) or cannot be removed by surgery (unresectable) and that it has progressed on previous standard treatment. ZEN003694 is an inhibitor...

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Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center