Familial Colorectal Cancer

Symptoms, Doctors, Treatments, Research & More

Condition 101

What is the definition of Familial Colorectal Cancer?

Familial colon cancer is a cluster of colon cancer within a family. Most cases of colon cancer occur sporadically in people with little to no family history of the condition. Approximately 3-5% of colon cancer is considered "hereditary" and is thought to be caused by an inherited predisposition to colon cancer that is passed down through a family in an autosomal dominant or autosomal recessive manner. In some of these families, the underlying genetic cause is not known; however, many of these cases are caused by changes (mutations) in the APC, MYH, MLH1, MSH2, MSH6, PMS2, EPCAM, PTEN, STK11, SMAD4, BMPR1A, NTHL1, POLE, and POLD1 genes (which are associated with hereditary cancer syndromes). An additional 10-30% of people diagnosed with colon cancer have a significant family history of the condition but have no identifiable mutation in a gene known to cause a hereditary predisposition to colon cancer. These clusters of colon cancer are likely due to a combination of gene(s) and other shared factors such as environment and lifestyle. High-risk cancer screening and other preventative measures such as prophylactic surgeries are typically recommended in people who have an increased risk for colon cancer based on their personal and/or family histories.

What are the alternative names for Familial Colorectal Cancer?

  • Colorectal cancer, familial

Latest Research

Latest Advance
  • Condition: NF1 Germline Mutation in Chinese Family with Colon Cancer
  • Journal: The Journal of international medical research
  • Treatment Used: Bevacizumab plus Capecitabine/Oxaliplatin Therapy
  • Number of Patients: 2
  • Published —
This case report describes a germline mutation in NF1 in two family members with colon cancer, for which the female patient was treated with bevacizumab plus capecitabine/oxaliplatin therapy.
Latest Advance
  • Condition: Chronic Radiation Proctopathy
  • Journal: Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • Treatment Used: Laparoscopic Parks Procedure
  • Number of Patients: 19
  • Published —
The study researched the safety and effectiveness of laparoscopic Parks procedure for patients with chronic radiation proctopathy.