Condition 101 About Familial Colorectal Cancer

What is the definition of Familial Colorectal Cancer?

Familial colon cancer is a cluster of colon cancer within a family. Most cases of colon cancer occur sporadically in people with little to no family history of the condition. Approximately 3-5% of colon cancer is considered "hereditary" and is thought to be caused by an inherited predisposition to colon cancer that is passed down through a family in an autosomal dominant or autosomal recessive manner. In some of these families, the underlying genetic cause is not known; however, many of these cases are caused by changes (mutations) in the APC, MYH, MLH1, MSH2, MSH6, PMS2, EPCAM, PTEN, STK11, SMAD4, BMPR1A, NTHL1, POLE, and POLD1 genes (which are associated with hereditary cancer syndromes). An additional 10-30% of people diagnosed with colon cancer have a significant family history of the condition but have no identifiable mutation in a gene known to cause a hereditary predisposition to colon cancer. These clusters of colon cancer are likely due to a combination of gene(s) and other shared factors such as environment and lifestyle. High-risk cancer screening and other preventative measures such as prophylactic surgeries are typically recommended in people who have an increased risk for colon cancer based on their personal and/or family histories.

What are the alternative names for Familial Colorectal Cancer?

  • Colorectal cancer, familial

Latest Advances On Familial Colorectal Cancer

  • Condition: Liver Metastasis from Rectal Cancer with Mitochondrial Disease
  • Journal: BMJ case reports
  • Treatment Used: Hepatectomy
  • Number of Patients: 1
  • Published —
This case report describes a mitochondrial disease patient with a liver metastasis that developed from rectal cancer.
  • Condition: Recurrent Gastric Cancer
  • Journal: Gan to kagaku ryoho. Cancer & chemotherapy
  • Treatment Used: Trifluridine/Tipiracil as a Late-Line Chemotherapy
  • Number of Patients: 1
  • Published —
The purpose of the study was to report a case of recurrence following radical gastrectomy for advanced adenocarcinoma of esophago-gastric junction using recommended chemotherapy regimens and Trifluridine/Tipiracile as a fifth-line chemotherapy.

Clinical Trials For Familial Colorectal Cancer