Non-Invasive Strategies for Early Detection of Uterine Cancer in Patients With Abnormal Uterine Bleeding
The study goal is to investigate a non-invasive approach to predict endometrial cancer (EC) risk, better understand disease progression and identify opportunities for intervention. This two-part case-cohort prospective study will recruit patients whose abnormal uterine bleeding is being evaluated via endometrial biopsy. Participants will complete an online health questionnaire, and a subset will be invited to self-collect vaginal samples for sequencing. Selected sequenced participants will be invited for longitudinal monitoring (questionnaires, wearable fitness tracker) and an additional vaginal self-collection to identify persistent genetic mutations or microbiome alterations 6-8 months later.
⁃ Study Part A:
• 40 years and older
• Experiencing unexplained abnormal uterine bleeding (i.e., not from IUD, etc.)
• Have an intact uterus
• Referred for an endometrial biopsy
⁃ Study Part B/Longitudinal monitoring:
• Those selected for sequencing (from Part A) and who retained their uterus.