Learn About Epidermal Nevus

What is the definition of Epidermal Nevus?

An epidermal nevus (plural: nevi) is an abnormal, noncancerous (benign) patch of skin caused by an overgrowth of cells in the outermost layer of skin (epidermis). Epidermal nevi are typically seen at birth or develop in early childhood. Affected individuals have one or more nevi that vary in size.

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What are the causes of Epidermal Nevus?

Several genes have been associated with different types of epidermal nevus. Mutations in the FGFR3 gene and PIK3CA gene account for about forty percent of keratinocytic epidermal nevi. Mutations in the HRAS gene are found in a majority of people with a nevus sebaceous and are also associated with keratinocytic epidermal nevi. Genes related to HRAS (called KRAS and NRAS) are less commonly involved in nevi sebaceous or keratinocytic epidermal nevi. Other genes, some of which have not been identified, are also involved in epidermal nevi.

How prevalent is Epidermal Nevus?

Epidermal nevi are estimated to occur in 1 to 3 in 1,000 people.

Is Epidermal Nevus an inherited disorder?

This condition is generally not inherited but arises from mutations in the body's cells that occur after conception. This type of alteration is called a somatic mutation.

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What are the latest Epidermal Nevus Clinical Trials?
12-Week Clinical Study to Determine the Safety, Tolerability, and Clinical Effect of NFX-179 Gel in Subjects With Epidermal Nevi

Summary: This study of NFX-179 is an open-label study, evaluating safety, tolerability, pharmacodynamic activity, and the clinical effect in subjects with Epidermal Nevus(ENS). NFX-179 is formulated as a gel for topical administration. NFX-179 has been shown in animal studies and in human extracts to suppress p-ERK with systemic absorption of NFX-179 following topical application to be extremely low, based...

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Development and Validation of an Investigator Global Assessment Score for Keratosis Pilaris

Summary: This validation study aims to develop a standardised investigator global assessment (IGA) score for keratosis pilaris and test the validity and reliability of the score through a one-day scoring exercise held at a private practice and compare it to a standard 0-4 IGA score specifically defined for keratosis pilaris.

Who are the sources who wrote this article ?

Published Date: August 01, 2016Published By: National Institutes of Health

What are the Latest Advances for Epidermal Nevus?
A Case Report: First Long-Term Treatment With Burosumab in a Patient With Cutaneous-Skeletal Hypophosphatemia Syndrome.
Darier disease successfully treated with a topical agent containing vitamin A (retinyl palmitate), vitamin E, and urea.
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Therapeutic Options for the Treatment of Darier's Disease: A Comprehensive Review of the Literature.