Epilepsy with Myoclonic-Atonic Seizures

Symptoms, Doctors, Treatments, Research & More

Condition 101

What is the definition of Epilepsy with Myoclonic-Atonic Seizures?

Epilepsy with myoclonic-atonic seizures is a rare epilepsy syndrome of early childhood. It is characterized by seizures of many different types, most often myoclonic-atonic, astatic, or generalized tonic-clonic seizures. Seizures can be followed by drop attacks, which can lead to falls and injuries. Absence seizures may occur. People with the condition may experience several seizures each day. The epilepsy may result in a delay or regression of skills.  Autistic features and ataxic (poorly controlled) movements have been reported in some cases.

Treatment may include valproic acid alone or with other antiepileptic drugs. Ketogenic (high fat, low carb) diet has been successful in some. Long term outlook ranges from persistent seizures that do not respond to treatment and intellectual disability, to complete seizure remission after several years and normal outcome. Changes in the SCN1A, SCN1B, GABRG2, CHD2, and SLC6A1 genes can cause or contribute to epilepsy with myoclonic-atonic seizures. However, in many cases the cause remains unknown. Epilepsy with myoclonic-atonic seizures can be inherited from an affected parent or occur for the first time in a family as a sporadic disease.

What are the alternative names for Epilepsy with Myoclonic-Atonic Seizures?

  • Myoclonic astatic epilepsy
  • Doose syndrome
  • Epilepsy with myoclonic-astatic seizures
  • Epilepsy with myoclono-astatic crisis

Top Global Doctors

Pasquale Striano
Genoa, 42, IT
Renzo Guerrini
Rima Nabbout
Paris, 11, FR

Latest Research

Latest Advance
  • Condition: Myoclonic and/or Absence Seizures
  • Journal: Seizure
  • Treatment Used: Perampanel
  • Number of Patients: 163
  • Published —
This study investigated the use of perampanel to reduce seizures in patients with myoclonic and/or absence seizures.
Latest Advance
  • Condition: COVID-19 in persons with epilepsy (Coronavirus)
  • Journal: Epilepsy research
  • Treatment Used: Chloroquine or hydroxychloroquine therapy
  • Number of Patients: 746
  • Published —
The study researched the use of chloroquine or hydroxychloroquine therapy for treating COVID-19 in persons with epilepsy (Coronavirus).

Clinical Trials

Clinical Trial
  • Status: Recruiting
  • Study Type: Device
  • Participants: 40
  • Start Date: November 1, 2020
Development of A Room Temperature Atomic Magnetrode System for Telemetry of Epileptic Seizures
Clinical Trial
  • Status: Not yet recruiting
  • Study Type: Device
  • Participants: 6
  • Start Date: November 2020
Transcranial Magnetic Stimulation to Measure Cortical Excitability in Dravet Syndrome