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RESting-state Functional MRI for Prediction of Post-surgical Prognosis In Pediatric Drug-Resistant Epilepsy

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

Resting-state functional MRI (r-fMRI) has emerged in recent years to analyze resting networks. It allows, without active participation of the patients, to identify and analyze the different functional brain networks. The analysis of r-fMRI can be done thanks to the graph theory, which is based on the based on the calculation of quantifiable parameters applied to the functional network studied, making it possible to assess its effectiveness. To the knowledge of the investigators, no study has used graph theory applied to r-fMRI data in order to obtain parameters useful for the useful parameters for the individual prognosis of children who have to be operation for drug-resistant lesional epilepsy.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 6
Maximum Age: 18
Healthy Volunteers: f
View:

• Patient aged between 6 and 18 years

• Receiving an MRI for lesional drug-resistant epilepsy

• Affiliated or beneficiary of a social security plan

• Whose parents or guardians have received information about the study and have given their express consent to participate in the study

Locations
Other Locations
France
Fondation A De Rothschild
RECRUITING
Paris
Contact Information
Primary
Sidney KRYSTAL
skrystal@for.paris
01 48 03 65 65
Backup
Amelie YAVCHITZ
ayavchitz@for.paris
01 48 03 65 65
Time Frame
Start Date: 2020-10-30
Estimated Completion Date: 2028-04
Participants
Target number of participants: 200
Treatments
Resting-state functional MRI (r-fMRI)
The MRI examination will be performed on a 3T multi-parametric MRI. Compared to the standard protocol, patients will benefit from an additional fMRI-r sequence, called resting state, and performed before injection of gadoline contrast.~A neuropsychological evaluation is performed as part of the 6 months prior to the procedure. These data will be used as a basis for the evaluation of language visual and language recovery.
Related Therapeutic Areas
Sponsors
Leads: Fondation Ophtalmologique Adolphe de Rothschild

This content was sourced from clinicaltrials.gov