Developmental and Epileptic Encephalopathy of Genetic Etiology: Natural History Through Reuse of Clinical Data / DEE-RETRO
Status: Recruiting
Location: See all (23) locations...
Study Type: Observational
SUMMARY
Developmental and Epileptic Encephalopathy (DEE) are a heterogeneous group of neurodevelopmental disorders linked to both epilepsy and its underlying etiology, independently of epileptiform activity. The creation of a database with retrospective follow-up of a large number of patients on a national scale will enable better knowledge of specific biomarkers, and thus a better classification and understanding of the natural evolution of DEE according to their etiology. This will enable better, more personalized therapeutic management of patients, depending on etiology and the presence or absence of these biomarkers. The investigators will also be able to draw up management recommendations, which are currently non-existent.
Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: f
View:
• Diagnosis of Developmental and Epileptic Encephalopathy
• Registered with or benefiting from a social security scheme.
Locations
Other Locations
France
CHU Amiens
NOT_YET_RECRUITING
Amiens
CH Angers
NOT_YET_RECRUITING
Angers
Chu Besancon
NOT_YET_RECRUITING
Besançon
CHU Bordeaux
NOT_YET_RECRUITING
Bordeaux
CHRU Brest
NOT_YET_RECRUITING
Brest
CHU Clermont-Ferrand
NOT_YET_RECRUITING
Clermont-ferrand
CHU Grenoble
NOT_YET_RECRUITING
Grenoble
CHU Lille
NOT_YET_RECRUITING
Lille
CHU Limoges
NOT_YET_RECRUITING
Limoges
CHU Lyon HCL
NOT_YET_RECRUITING
Lyon
Assistance Publique Hopitaux de Marseille
NOT_YET_RECRUITING
Marseille
CHU de Nancy
NOT_YET_RECRUITING
Nancy
Hopitaux Pediatriques de Nice CHU Lenval
NOT_YET_RECRUITING
Nice
CHU Pitié Salpétrière
NOT_YET_RECRUITING
Paris
CHU Robert Debré
NOT_YET_RECRUITING
Paris
Hôpital Armand Trousseau
NOT_YET_RECRUITING
Paris
Necker-Enfants Malades Hospital
RECRUITING
Paris
Chu Reims
NOT_YET_RECRUITING
Reims
CHU Rennes
NOT_YET_RECRUITING
Rennes
CHU Strasbourg
NOT_YET_RECRUITING
Strasbourg
CHU Toulouse
NOT_YET_RECRUITING
Toulouse
CHRU Tours
NOT_YET_RECRUITING
Tours
Hôpital André Mignot (CH Versailles)
NOT_YET_RECRUITING
Versailles
Contact Information
Primary
Rima Nabbout, Pr
rima.nabbout@aphp.fr
+33144381536
Time Frame
Start Date:2024-10-31
Estimated Completion Date:2026-12-31
Participants
Target number of participants:400
Treatments
Patient
Patient inclusion criteria:~* Diagnosis of developmental and epileptic encephalopathies~* Affiliation with, or beneficiary of, a social security scheme~Criteria for non-inclusion of patients:~* Opposition of the patient or his/her parents in the case of minors to the re-use of data for this study.~* Persons subject to a safeguard of justice measure
Control patient
Inclusion criteria for controls:~* Patients who, as part of their routine health care, require an EEG examination~* Patients with sufficient follow-up to rule out a diagnosis of epilepsy, including developmental and epileptic encephalopathies~* Enrolled in or receiving social security benefits~Criteria for non-inclusion of controls :~* Patient with a neurological or extra-neurological disease that may have an impact on the child's neurological development and outcome~* Opposition of the patient or his/her parents to the re-use of data for this study~* Persons subject to a safeguard of justice measure