Impact of Epileptic Discharge on the Structural Connectivity of the Developing Brain: Combination of Intracerebral Stereotactic Electroencephalography Recording and Diffusion Tensor Imaging in Children With Drug-resistant Focal Epilepsy

Status: Recruiting
Location: See location...
Intervention Type: Other, Device
Study Type: Observational
SUMMARY

Focal epilepsy is associated with widespread alterations in structural brain connectivity, often present at the disease onset and related to learning disabilities. Whether ongoing seizure activity contributes to network pathology is a matter of debate. This study intends to measure the impact of seizures on structural connectivity on a local and on a global level. In children examined with intracerebral electrodes to evaluate whether a surgical cure can be proposed, we combine intracerebral stereotactic electroencephalography (EEG) recordings with diffusion weighted imaging of white matter fibers. On the local level, the study will quantify the number of deficient connections in the seizure onset zone. On a global level, the study will compare the white matter fibers of the left and right hemisphere to probe whether physiological language lateralization is preserved.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 1
Maximum Age: 16
Healthy Volunteers: f
View:

• \- Drug resistant focal epilepsy

• \- without drug resistant focal epilepsy

Locations
Other Locations
France
Fondation Ophtalmologique A. de Rothschild
RECRUITING
Paris
Contact Information
Primary
Laurence Salomon, MD PhD
lsalomon@for.paris
0148036431
Backup
Vera Dinkelacker, MD PhD
vdinkelacker@for.paris
0148036853
Time Frame
Start Date: 2017-12-19
Estimated Completion Date: 2026-07
Participants
Target number of participants: 82
Treatments
Children / adolescents with drug-resistant focal epilepsy
Children / adolescents without drug-resistant focal epilepsy
Related Therapeutic Areas
Sponsors
Leads: Fondation Ophtalmologique Adolphe de Rothschild

This content was sourced from clinicaltrials.gov