• Subjects must have histologically or cytologically confirmed esophageal, colorectal or pancreatic adenocarcinoma (inclusive of high grade dysplasia and cystic neoplasms) on a biopsy prior to surgery and must be scheduled for surgical resection, inclusive of endoscopic mucosal resection, of the primary tumor. Subjects at any cancer stage will be enrolled.

• Subjects may have previously received pre-operative radiation therapy and neoadjuvant chemotherapy.

• Age of 18 years or older.

• Subjects must be able and willing to follow study procedures and instructions.

• Subjects must have received and signed an informed consent form.

• Subjects must be sufficiently healthy to undergo surgery or an endoscopic procedure.

• Subjects must have normal organ and marrow function as defined below:

‣ Leukocytes \>/= 3,000/mcL

⁃ Absolute neutrophil count \>/= 1,500/mcL

⁃ Platelets \>/= 100,000/mcL

⁃ total bilirubin within normal institutional limits (except in cases of malignant biliary obstruction)

⁃ AST (SGOT)/ALT (SGPT) \</= 2.5 X institutional upper limit of normal (\</= 5 x ULN in cases of malignant biliary obstruction)

⁃ Creatinine within normal institutional limits or creatinine clearance \>/= 60 mL/min/1.73 m2 for subjects with creatinine levels above institutional normal.

• Women of child-bearing potential must agree to use adequate contraception (hormonal or barrier method of birth control, abstinence) starting the day entering the study, and for 60 days after injection of the imaging agent. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately.

• Subjects with ECOG performance status of 0 or 1.