MediFind
Condition

Pancreatic Cancer

Symptoms, Doctors, Treatments, Research & More

Condition 101

What is the definition of Pancreatic Cancer?

Pancreatic cancer is cancer that starts in the pancreas.

What are the alternative names for Pancreatic Cancer?

Pancreatic cancer; Cancer - pancreas

What are the causes for Pancreatic Cancer?

The pancreas is a large organ behind the stomach. It makes and releases enzymes into the intestines that help the body digest and absorb food, especially fats. The pancreas also makes and releases insulin and glucagon. These are hormones that help the body control blood sugar levels.

There are different types of pancreatic cancers. The type depends on the cell the cancer develops in. Examples include:

  • Adenocarcinoma, the most common type of pancreatic cancer
  • Other more rare types include glucagonoma, insulinoma, islet cell tumor, VIPoma

The exact cause of pancreatic cancer is unknown. It is more common in people who:

  • Are obese
  • Have a diet high in fat and low in fruits and vegetables
  • Have diabetes
  • Have long-term exposure to certain chemicals
  • Have long-term inflammation of the pancreas (chronic pancreatitis)
  • Smoke

The risk for pancreatic cancer increases with age. Family history of the disease also slightly increases the chance of developing this cancer.

What are the symptoms for Pancreatic Cancer?

A tumor (cancer) in the pancreas may grow without any symptoms at first. This means the cancer is often advanced when it is first found.

Symptoms of pancreatic cancer include:

  • Diarrhea
  • Dark urine and clay-colored stools
  • Fatigue and weakness
  • Sudden increase in blood sugar level (diabetes)
  • Jaundice (a yellow color in the skin, mucous membranes, or white part of the eyes) and itching of the skin
  • Loss of appetite and weight loss
  • Nausea and vomiting
  • Pain or discomfort in the upper part of the belly or abdomen

What are the current treatments for Pancreatic Cancer?

Treatment for adenocarcinoma depends on the stage of the tumor.

Surgery may be done if the tumor has not spread or has spread very little. Along with surgery, chemotherapy or radiation therapy or both may be used before or after surgery. A small number of people can be cured with this treatment approach.

When the tumor has not spread out of the pancreas but cannot be surgically removed, chemotherapy and radiation therapy together may be recommended.

When the tumor has spread (metastasized) to other organs such as the liver, chemotherapy alone is usually used.

With advanced cancer, the goal of treatment is to manage pain and other symptoms. For example, if the tube that carries bile is blocked by the pancreatic tumor, a procedure to place a tiny metal tube (stent) may be done to open the blockage. This can help relieve jaundice, and itching of the skin.

What are the support groups for Pancreatic Cancer?

You can ease the stress of illness by joining a cancer support group. Sharing with others who have common experiences and problems can help you not feel alone.

What is the outlook (prognosis) for Pancreatic Cancer?

Some people with pancreatic cancer that can be surgically removed are cured. But in most people, the tumor has spread and cannot be completely removed at the time of diagnosis.

Chemotherapy and radiation are often given after surgery to increase the cure rate (this is called adjuvant therapy). For pancreatic cancer that cannot be removed completely with surgery or cancer that has spread beyond the pancreas, a cure is not possible. In this case, chemotherapy is given to improve and extend the person's life.

When should I contact a medical professional for Pancreatic Cancer?

Call for an appointment with your provider if you have:

  • Abdominal or back pain that does not go away
  • Persistent loss of appetite
  • Unexplained fatigue or weight loss
  • Other symptoms of this disorder

How do I prevent Pancreatic Cancer?

Preventive measures include:

  • If you smoke, now is the time to quit.
  • Eat a diet high in fruits, vegetables, and whole grains.
  • Exercise regularly to stay at a healthy weight.
Digestive
Endocrine
Pancreatic
Pancreas
Biliary

REFERENCES

Jesus-Acosta AD, Narang A, Mauro L, Herman J, Jaffee EM, Laheru DA. Carcinoma of the pancreas. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 78.

National Cancer Institute website. Pancreatic cancer treatment (PDQ) - health professional version. www.cancer.gov/types/pancreatic/hp/pancreatic-treatment-pdq. Updated July 15, 2019. Accessed August 27, 2019.

National Comprehensive Cancer Network website. NCCN clinical practice guidelines in oncology: pancreatic adenocarcinoma. Version 3.2019. www.nccn.org/professionals/physician_gls/pdf/pancreatic.pdf. Updated July 2, 2019. Accessed August 27, 2019.

Shires GT, Wilfong LS. Pancreatic cancer, cystic pancreatic neoplasms, and other nonendocrine pancreatic tumors. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 10th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 60.

Latest Research

Latest Advance
Study
  • Condition: Advanced Solid Tumors
  • Journal: Journal for immunotherapy of cancer
  • Treatment Used: AMG 820 with Pembrolizumab
  • Number of Patients: 116
  • Published —
This study tested the safety and efficacy of using AMG 820 with pembrolizumab to treat patients with advanced soild tumors.
Latest Advance
Study
  • Condition: Locally Advanced Pancreatic Cancer
  • Journal: Zhonghua wai ke za zhi [Chinese journal of surgery]
  • Treatment Used: Intraoperative Ultrasound-Guided Irreversible Electroporation with Chemotherapy
  • Number of Patients: 64
  • Published —
This study tested the safety and efficacy of combining an intraoperative ultrasound-guided irreversible electroporation with chemotherapy to treat patients with locally advanced pancreatic cancer.

Clinical Trials

Clinical Trial
Drug
  • Status: Not yet recruiting
  • Study Type: Drug
  • Participants: 29
  • Start Date: May 29, 2021
BrafPanc: A Phase II Trial of Binimetinib in Combination With Encorafenib in Patients With Pancreatic Malignancies and a Somatic BRAFV600E Mutation
Clinical Trial
Other
  • Status: Not yet recruiting
  • Study Type: Other
  • Participants: 200
  • Start Date: January 1, 2021
Prognostic Role of Circulating Tumor DNA in Resectable Pancreatic Cancer