Targeted Elimination Diet in EoE Patients Following Identification of Trigger Nutrients Using Confocal Laser Endomicroscopy
Using confocal laser endomicroscopy (CLE), gastrointestinal allergic reactions to certain foods in the duodenum will be evaluated on a cellular level. After that, a personalized exclusion diet will be followed based on the CLE results for 6 weeks, sham-controlled, in a cross-over fashion. Gastroscopy with esophageal biopsies will be repeated after each diet.
• Eosinophilic Esophagitis, with peak eosinophil count of \>15 eos/HPF and symptoms of dysphagia at least 2 days per week
• Patients have had a trial of high-dose PPI for at least 8 weeks, with either documented non-response or intolerance to the medication
• Patients aged between 18 and 70 years old
• Signed written informed consent
• Eosinophilic Esophagitis, with peak eosinophil count of \>15 eos/HPF and symptoms of dysphagia at least 2 days per week
• Patients have had a trial of high-dose PPI for at least 8 weeks, with either documented non-response or intolerance to the medication
• Patients aged between 18 and 70 years old
• Signed written informed consent