Condition 101 About Factor 12 Deficiency

What is the definition of Factor 12 Deficiency?

Factor XII deficiency is an inherited disorder that affects a protein (factor XII) involved in blood clotting. While a lack of factor XII does not cause affected individuals to bleed abnormally, the blood takes longer than normal to clot in a test tube. The condition is usually discovered when prolonged clotting is noticed in the process of running other laboratory tests. Factor XII deficiency is caused by mutations in the F12 gene. It is inherited in an autosomal recessive manner. 

What are the alternative names for Factor 12 Deficiency?

  • HAF deficiency
  • Hageman factor deficiency
  • F12 deficiency
  • Coagulation factor 12 deficiency
  • Factor 12 deficiency

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