Factor 13 DeficiencySymptoms, Doctors, Treatments, Advances & More
Learn About Factor 13 Deficiency
Factor XIII deficiency is a rare bleeding disorder. Researchers have identified an inherited form and a less severe form that is acquired during a person's lifetime.
Inherited factor XIII deficiency results from mutations in the F13A1 gene or, less commonly, the F13B gene. These genes provide instructions for making the two parts (subunits) of a protein called factor XIII. This protein plays a critical role in the coagulation cascade, which is a series of chemical reactions that forms blood clots in response to injury. After an injury, clots seal off blood vessels to stop bleeding and trigger blood vessel repair. Factor XIII acts at the end of the cascade to strengthen and stabilize newly formed clots, preventing further blood loss.
Inherited factor XIII deficiency affects 1 to 3 per million people worldwide. Researchers suspect that mild factor XIII deficiency, including the acquired form of the disorder, is underdiagnosed because many affected people never have a major episode of abnormal bleeding that would lead to a diagnosis.
Inherited factor XIII deficiency is considered to have an autosomal recessive pattern of inheritance, which means that it results when both copies of either the F13A1 gene or the F13B gene in each cell have mutations.
Reading Hospital Cardiology - West Reading
. Dr. Dendall is rated as an Advanced provider by MediFind in the treatment of Factor 13 Deficiency. He is also highly rated in 43 other conditions, according to our data. His clinical expertise encompasses Heart Failure with Preserved Ejection Fraction (HFpEF), Heart Failure, Pulmonary Edema, and Atrial Fibrillation. Dr. Dendall is board certified in American Osteopathic Board Of Internal Medicine.
Flora Peyvandi practices practicing medicine in Milan, Italy. Ms. Peyvandi is rated as an Elite expert by MediFind in the treatment of Factor 13 Deficiency. She is also highly rated in 37 other conditions, according to our data. Her clinical expertise encompasses Blood Clots, Hemophilia A, Von Willebrand Disease (VWD), Synovectomy, and Bone Marrow Transplant.
Verena Schroeder practices practicing medicine in Bern, Switzerland. Ms. Schroeder is rated as an Elite expert by MediFind in the treatment of Factor 13 Deficiency. She is also highly rated in 2 other conditions, according to our data. Her clinical expertise encompasses Factor 13 Deficiency, Blood Clots, Mesenteric Venous Thrombosis, Deep Vein Thrombosis, and Bone Marrow Transplant.
Published Date: January 01, 2019
Published By: National Institutes of Health