Learn About Factor 13 Deficiency

What is the definition of Factor 13 Deficiency?

Factor XIII deficiency is a rare bleeding disorder. Researchers have identified an inherited form and a less severe form that is acquired during a person's lifetime.

Save information for later
Sign Up
What are the causes of Factor 13 Deficiency?

Inherited factor XIII deficiency results from mutations in the F13A1 gene or, less commonly, the F13B gene. These genes provide instructions for making the two parts (subunits) of a protein called factor XIII. This protein plays a critical role in the coagulation cascade, which is a series of chemical reactions that forms blood clots in response to injury. After an injury, clots seal off blood vessels to stop bleeding and trigger blood vessel repair. Factor XIII acts at the end of the cascade to strengthen and stabilize newly formed clots, preventing further blood loss.

How prevalent is Factor 13 Deficiency?

Inherited factor XIII deficiency affects 1 to 3 per million people worldwide. Researchers suspect that mild factor XIII deficiency, including the acquired form of the disorder, is underdiagnosed because many affected people never have a major episode of abnormal bleeding that would lead to a diagnosis.

Is Factor 13 Deficiency an inherited disorder?

Inherited factor XIII deficiency is considered to have an autosomal recessive pattern of inheritance, which means that it results when both copies of either the F13A1 gene or the F13B gene in each cell have mutations.

Who are the top Factor 13 Deficiency Local Doctors?
Learn about our expert tiers
Learn more
What are the latest Factor 13 Deficiency Clinical Trials?
Match to trials
Find the right clinical trials for you in under a minute
Get started
Who are the sources who wrote this article ?

Published Date: January 01, 2019Published By: National Institutes of Health

What are the Latest Advances for Factor 13 Deficiency?
Tired of the same old research?
Check Latest Advances