Learn About Factor 5 Deficiency

What is the definition of Factor 5 Deficiency?

Factor V deficiency is a bleeding disorder that is passed down through families. It affects the ability of the blood to clot.

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What are the alternative names for Factor 5 Deficiency?

Parahemophilia; Owren disease; Bleeding disorder - factor V deficiency

What are the causes of Factor 5 Deficiency?

Blood clotting is a complex process involving as many as 20 different proteins in blood plasma. These proteins are called blood coagulation factors.

Factor V deficiency is caused by a lack of factor V. When certain blood clotting factors are low or missing, your blood does not clot properly.

Factor V deficiency is rare. It may be caused by:

  • A defective factor V gene passed down through families (inherited)
  • An antibody that interferes with normal factor V function

You can develop an antibody that interferes with factor V:

  • After giving birth
  • After being treated with a certain type of fibrin glue
  • After surgery
  • With autoimmune diseases and certain cancers

Sometimes the cause is unknown.

The disease is similar to hemophilia, except bleeding into joints is less common. In the inherited form of factor V deficiency, a family history of a bleeding disorder is a risk factor.

What are the symptoms of Factor 5 Deficiency?

Excessive bleeding with menstrual periods and after childbirth often occurs. Other symptoms can include:

  • Bleeding into the skin
  • Bleeding of the gums
  • Excessive bruising
  • Nosebleeds
  • Prolonged or excessive loss of blood with surgery or trauma
  • Umbilical stump bleeding
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What are the current treatments for Factor 5 Deficiency?

You will be given fresh blood plasma or fresh frozen plasma infusions during a bleeding episode or after surgery. These treatments will correct the deficiency temporarily.

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What is the outlook (prognosis) for Factor 5 Deficiency?

The outlook is good with diagnosis and proper treatment.

What are the possible complications of Factor 5 Deficiency?

Severe bleeding (hemorrhage) could occur.

When should I contact a medical professional for Factor 5 Deficiency?

Go to the emergency room or call 911 or the local emergency number if you have an unexplained or prolonged loss of blood.

Blood clot formation
Blood clots
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What are the Latest Advances for Factor 5 Deficiency?
Successful management of acquired factor V deficiency developing shortly after induction of hemodialysis.
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Acquired Factor V Deficiency Associated with CFPM Administration.
Who are the sources who wrote this article ?

Published Date: January 25, 2022
Published By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Gailani D, Wheeler AP, Neff AT. Rare coagulation factor deficiencies. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 137.

Ragni MV. Hemorrhagic disorders: coagulation factor deficiencies. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 165.

Scott JP, Flood VH. Hereditary clotting factor deficiencies (bleeding disorders). In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 503.