Factor V deficiency is a bleeding disorder that is passed down through families. It affects the ability of the blood to clot.
Parahemophilia; Owren disease; Bleeding disorder - factor V deficiency
Blood clotting is a complex process involving as many as 20 different proteins in blood plasma. These proteins are called blood coagulation factors.
Factor V deficiency is caused by a lack of factor V. When certain blood clotting factors are low or missing, your blood does not clot properly.
Factor V deficiency is rare. It may be caused by:
You can develop an antibody that interferes with factor V:
Sometimes the cause is unknown.
The disease is similar to hemophilia, except bleeding into joints is less common. In the inherited form of factor V deficiency, a family history of a bleeding disorder is a risk factor.
Excessive bleeding with menstrual periods and after childbirth often occurs. Other symptoms can include:
You will be given fresh blood plasma or fresh frozen plasma infusions during a bleeding episode or after surgery. These treatments will correct the deficiency temporarily.
Elisabetta Castoldi practices in Maastricht, Netherlands. Castoldi is rated as an Elite expert by MediFind in the treatment of Factor 5 Deficiency. She is also highly rated in 7 other conditions, according to our data. Her top areas of expertise are Factor 5 Deficiency, Factor V Leiden Thrombophilia, Protein S Deficiency, and Mesenteric Venous Thrombosis.
Paolo Simioni practices in Padova, Italy. Simioni is rated as an Elite expert by MediFind in the treatment of Factor 5 Deficiency. He is also highly rated in 23 other conditions, according to our data. His top areas of expertise are Mesenteric Venous Thrombosis, Factor 5 Deficiency, Protein S Deficiency, Liver Transplant, and Kidney Transplant.
Luca Spiezia practices in Padova, Italy. Spiezia is rated as an Elite expert by MediFind in the treatment of Factor 5 Deficiency. He is also highly rated in 15 other conditions, according to our data. His top areas of expertise are Factor 5 Deficiency, Mesenteric Venous Thrombosis, Venous Thromboembolism (VTE), Deep Vein Thrombosis, and Liver Transplant.
The outlook is good with diagnosis and proper treatment.
Severe bleeding (hemorrhage) could occur.
Go to the emergency room or call 911 or the local emergency number if you have an unexplained or prolonged loss of blood.
Published Date: January 25, 2022
Published By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Gailani D, Wheeler AP, Neff AT. Rare coagulation factor deficiencies. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 137.
Ragni MV. Hemorrhagic disorders: coagulation factor deficiencies. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 165.
Scott JP, Flood VH. Hereditary clotting factor deficiencies (bleeding disorders). In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 503.