Familial Adenomatous Polyposis Overview
Learn About Familial Adenomatous Polyposis
Familial adenomatous polyposis (FAP) is an inherited disorder characterized by cancer of the large intestine (colon) and rectum. People with the classic type of familial adenomatous polyposis may begin to develop multiple noncancerous (benign) growths (polyps) in the colon as early as their teenage years. Unless the colon is removed, these polyps will become malignant (cancerous). The average age at which an individual develops colon cancer in classic familial adenomatous polyposis is 39 years. Some people have a variant of the disorder, called attenuated familial adenomatous polyposis, in which polyp growth is delayed. The average age of colorectal cancer onset for attenuated familial adenomatous polyposis is 55 years.
Mutations in the APC gene cause both classic and attenuated familial adenomatous polyposis. These mutations affect the ability of the cell to maintain normal growth and function. Cell overgrowth resulting from mutations in the APC gene leads to the colon polyps seen in familial adenomatous polyposis. Although most people with mutations in the APC gene will develop colorectal cancer, the number of polyps and the time frame in which they become malignant depend on the location of the mutation in the gene.
The reported incidence of familial adenomatous polyposis varies from 1 in 7,000 to 1 in 22,000 individuals.
Familial adenomatous polyposis can have different inheritance patterns.
Warren Clinic Inc
Ajay Sangal is a Gastroenterologist in Muskogee, Oklahoma. Dr. Sangal and is rated as a Distinguished provider by MediFind in the treatment of Familial Adenomatous Polyposis. His top areas of expertise are Lower Esophageal Ring, Benign Esophageal Stricture, Gastritis, Gastrectomy, and Gastrostomy.
Northeastern Health System
William Simpson is a Gastroenterologist in Tahlequah, Oklahoma. Dr. Simpson and is rated as a Distinguished provider by MediFind in the treatment of Familial Adenomatous Polyposis. His top areas of expertise are Esophageal Varices, Benign Esophageal Stricture, Lower Esophageal Ring, Endoscopy, and Gastrectomy.
St John Physicians Inc
Stephen Kirkpatrick is a Gastroenterologist in Tulsa, Oklahoma. Dr. Kirkpatrick has been practicing medicine for over 43 years and is rated as a Distinguished provider by MediFind in the treatment of Familial Adenomatous Polyposis. His top areas of expertise are Benign Esophageal Stricture, Lower Esophageal Ring, Esophagitis, Gastrectomy, and Colonoscopy.
Summary: This phase IIa trial investigates if giving obeticholic acid (OCA) is safe and has a beneficial effect on the number of polyps in the small bowel and colon in patients with familial adenomatous polyposis (FAP). FAP is a rare gene defect that increases the risk of developing cancer of the intestines and colon. OCA is a drug similar to a bile acid the body makes. It is fluid made and released by the...
Summary: The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer patients, high-risk individuals, and normal controls. The distinct characteristic of the iCaRe2 is its geographical coverage, with a significant percentage of small and rur...
Published Date: October 01, 2013
Published By: National Institutes of Health