Familial chronic mucocutaneous candidiasis (CMC) is a genetic disorder that causes frequent, persistent Candida fungal infections, commonly known as yeast infections.

Symptoms of familial chronic mucocutaneous candidiasis include frequent, persistent skin, nail, and mucous membrane infections that begin in early childhood. The skin infections are characterized by a rash that develops into crusty, thickened patches. Many individuals with familial chronic mucocutaneous candidiasis have thickened, cracked, and discolored fingernail and toenails. Additional symptoms may include thrush (fungal infection in mouth), inflammation of the lips (cheilitis), hair loss, bloating, diarrhea, or constipation, and vaginal yeast infections. Infants with familial chronic mucocutaneous candidiasis may have persistent diaper rash. In rare instances, some affected individuals may develop the life-threatening condition of systemic candidiasis.

While there is not cure for the inherited condition, treatment for familial chronic mucocutaneous candidiasis involves the use of antifungal drugs, such as miconazole and amphotericin B.