Familial Hyperaldosteronism Overview
Learn About Familial Hyperaldosteronism
Familial hyperaldosteronism is a group of inherited conditions in which the adrenal glands, which are small glands located on top of each kidney, produce too much of the hormone aldosterone. Aldosterone helps control the amount of salt retained by the kidneys. Excess aldosterone causes the kidneys to retain more salt than normal, which in turn increases the body's fluid levels and blood pressure. People with familial hyperaldosteronism may develop severe high blood pressure (hypertension), often early in life. Without treatment, hypertension increases the risk of strokes, heart attacks, and kidney failure.
The various types of familial hyperaldosteronism have different genetic causes. Familial hyperaldosteronism type I is caused by the abnormal joining together (fusion) of two similar genes called CYP11B1 and CYP11B2, which are located close together on chromosome 8. These genes provide instructions for making two enzymes that are found in the adrenal glands.
The prevalence of familial hyperaldosteronism is unknown. Familial hyperaldosteronism type II appears to be the most common variety. All types of familial hyperaldosteronism combined account for fewer than 1 out of 10 cases of hyperaldosteronism.
This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder.
Cleveland Clinic
Eren Berber is a General Surgeon in Solon, Ohio. Dr. Berber and is rated as an Advanced provider by MediFind in the treatment of Familial Hyperaldosteronism. His top areas of expertise are Hyperparathyroidism, Pheochromocytoma, Thyroid Cancer, Thyroidectomy, and Parathyroidectomy. Dr. Berber is currently accepting new patients.
Richard Banozic is an Internal Medicine provider in Ravenna, Ohio. Dr. Banozic and is rated as an Experienced provider by MediFind in the treatment of Familial Hyperaldosteronism. His top areas of expertise are ALK-Positive Non-Small Cell Lung Cancer, Lung Adenocarcinoma, Small Cell Lung Cancer (SCLC), and EGFR Positive Lung Cancer.
Cleveland Clinic
Leann Olansky is an Endocrinologist in East Cleveland, Ohio. Dr. Olansky and is rated as an Advanced provider by MediFind in the treatment of Familial Hyperaldosteronism. Her top areas of expertise are Hyperparathyroidism, Type 2 Diabetes (T2D), Trimethylaminuria, and Type 1 Diabetes (T1D).
Published Date: April 01, 2014
Published By: National Institutes of Health