Effect of Cardioneuroablation vs Midodrine on Syncope Recurrence Among Patients With Vasovagal Syncope: The CAMPAIGN Randomized Clinical Trial
This is a prospective, international multi-center, open-labeled, randomized trial. The investigator speculated that CNA prevents more patients with moderate to severe VVS from syncope recurrence compared to midodrine.
• Age ≥ 18 years of age
• Calgary Syncope Symptom Score ≥ -2 points
• Positive response to head-up tilt test
• With syncope episodes more than 3 times in the preceding year
• A proven failure of non-pharmacologic treatment, including reassurance regarding the benign prognosis, education about the avoidance of situations and triggers initiating syncope, application of PCM during the occurrence of prodromal symptoms, and lifestyle modifications(adequate fluid intake and salt supplementation), according to the guideline
• Willingness to comply with follow-up requirements and to sign the informed consent