Assessment of Stroke Volume and Cardiac Output in Response to Varying Heart Rates and Body Position - a Pacemaker Based Study
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The investigators will seek to determine the effects of different heart rates on both stroke volume and cardiac output using non-invasive hemodynamic assessments. In order to safely manipulate the HR, the investigators will study patients with permanent pacemakers in whom heart rate manipulation can be done in a safe and non-invasive manner.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: f
View:
• Age 18-70 years (inclusive)
• Implanted permanent pacemaker or implanted defibrillator capable of atrial and ventricular pacing
• LV ejection fraction \>50%
Locations
Other Locations
Canada
University of Calgary
RECRUITING
Calgary
Contact Information
Primary
Satish R Raj, MD MSCI
satish.raj@ucalgary.ca
4032106152
Time Frame
Start Date: 2018-01-01
Estimated Completion Date: 2028-01-01
Participants
Target number of participants: 25
Treatments
Experimental: Stroke volume and cardiac output
Pacing runs will occur at the following rates:~* 50 beats per minute (bpm)~* 60 bpm~* 70 bpm~* 80 bpm~* 90 bpm~* 100 bpm~* 110 bpm~* 120 bpm~* 130 bpm~The finger blood pressure cuff will be calibrated between pacing runs.~Following the final pacing run while supine, the patient will be given 10 minutes to rest prior to the upright portion of the study. They will then be strapped into the table (so they will not fall) and then they will be tilted up to \>70 degrees (almost standing up). They will stand for \~10 minutes prior to commencing the next pacing trains.
Related Therapeutic Areas
Sponsors
Leads: University of Calgary