Familial Paroxysmal Nonkinesigenic DyskinesiaSymptoms, Doctors, Treatments, Advances & More
Learn About Familial Paroxysmal Nonkinesigenic Dyskinesia
Familial paroxysmal nonkinesigenic dyskinesia is a disorder of the nervous system that causes episodes of involuntary movement. Paroxysmal indicates that the abnormal movements come and go over time. Nonkinesigenic means that episodes are not triggered by sudden movement. Dyskinesia broadly refers to involuntary movement of the body.
Mutations in the PNKD gene can cause familial paroxysmal nonkinesigenic dyskinesia. The function of the protein produced from the PNKD gene is unknown, although it is thought to play an important role in normal brain function. The PNKD protein may help control the release of chemicals in the brain called neurotransmitters, which allow nerve cells (neurons) to communicate with each other.
Familial paroxysmal nonkinesigenic dyskinesia is a very rare disorder. Its prevalence is estimated to be 1 in 5 million people.
This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is typically sufficient to cause the disorder. In all reported cases caused by PNKD gene mutations, an affected person has inherited the mutation from one parent. A small number of people with the altered gene have not developed signs and symptoms of the condition, a situation known as reduced penetrance.
Movement Disorders Clinic
Rohit Dhall is a Neurologist practicing medicine in Little Rock, Arkansas. Dr. Dhall is rated as a Distinguished provider by MediFind in the treatment of Familial Paroxysmal Nonkinesigenic Dyskinesia. He is also highly rated in 25 other conditions, according to our data. His clinical expertise encompasses Movement Disorders, Parkinson's Disease, Drug Induced Dyskinesia, Essential Tremor, and Deep Brain Stimulation. Dr. Dhall is currently accepting new patients.
University Of Cincinnati Gardner Neuroscience Institute
Alberto Espay is a Neurologist practicing medicine in Cincinnati, Ohio. Dr. Espay is rated as a Distinguished provider by MediFind in the treatment of Familial Paroxysmal Nonkinesigenic Dyskinesia. He is also highly rated in 81 other conditions, according to our data. His clinical expertise encompasses Movement Disorders, Parkinson's Disease, Drug Induced Dyskinesia, Focal Dystonia, and Deep Brain Stimulation. Dr. Espay is currently accepting new patients.
Tower Health Medical Group Physical Medicine & Rehabilitation - Wyomissing
Li-hong Lu is a Physiatrist practicing medicine in Wyomissing, Pennsylvania. Dr. Lu is rated as an Advanced provider by MediFind in the treatment of Familial Paroxysmal Nonkinesigenic Dyskinesia. She is also highly rated in 7 other conditions, according to our data. Her clinical expertise encompasses Hemiplegia, Drug Induced Dyskinesia, Aromatic L-Amino Acid Decarboxylase (AADC) Deficiency, and Dopa-Responsive Dystonia. Dr. Lu is board certified in American Board Of Physical Medicine And Rehabilitation.
Published Date: August 01, 2017
Published By: National Institutes of Health