Identification of Women With Severe Insulin Resistant Syndromes of Genetic Origin Among Patients With Classic Polycystic Ovary Syndrome (PCOS)
Status: Recruiting
Location: See location...
Intervention Type: Other, Genetic
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Diagnostic case-control study (1 case for 2 controls). Inclusion of patients with severe insulin resistance syndrome of genetic origin, then inclusion of controls: patients examined for PCOS in day hospital with matching age (+/- 5 years) and Body mass index (+/- 5kg/m2).
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 45
Healthy Volunteers: f
View:
• Women aged ≥ 18 years and \< 45 years ;
• Discontinuation of estrogen-progestin therapyfor at least 3 months ;
• Signed informed consent ;
• Social security affiliation.
⁃ Case (n=25):
⁃ \- Patient with a lipodystrophic syndrome due to a known pathogenic variant of the LMNA gene.
⁃ Control (n=50), :
⁃ \- patient consulting for polycystic ovary syndrome (PCOS according to the Rotterdam criteria) in day hospital matched on age +/-5 years and BMI+/-5 kg/m2.
Locations
Other Locations
France
Service Endocrinologie, Hôpital St Antoine
RECRUITING
Paris
Contact Information
Primary
Sophie LAMOTHE, Doctor
sophie.lamothe@aphp.fr
0149282406
Backup
Camille VATIER, Doctor
camille.vatier@aphp.fr
0149282406
Time Frame
Start Date: 2026-07-21
Estimated Completion Date: 2028-01
Participants
Target number of participants: 81
Treatments
Other: Case
Patient with a Lipodystrophy Familial Partial due to a known pathogenic variant of the LMNA gene
Other: Control
Patient consulting for polycystic ovary syndrome in day hospital matched on age +/-5 years and BMI+/-5 kg/m2
Related Therapeutic Areas
Sponsors
Leads: Assistance Publique - Hôpitaux de Paris