What is the definition of Familial Prostate Cancer?

Familial prostate cancer is a cluster of prostate cancer within a family. Most cases of prostate cancer occur sporadically in people with no family history of the condition. However, approximately 5% to 10% of prostate cancer cases are believed to be primarily caused by a genetic predisposition to the condition. In many families, the underlying genetic cause is unknown; however, some of these cases are caused by changes (mutations) in the BRCA1, BRCA2, HOXB13, or several other genes. Other cases are likely due to a combination of gene(s) and other shared factors such as environment and lifestyle. High-risk cancer screening at an earlier age is typically recommended in men who have an increased risk for prostate cancer based on personal and/or family histories.

What are the alternative names for Familial Prostate Cancer?

  • Hereditary prostate cancer
  • Prostate cancer, familial
  • Prostate cancer, hereditary
  • Condition: Prostate Cancer
  • Journal: Lancet (London, England)
  • Treatment Used: Transdermal Estradiol
  • Number of Patients: 1694
  • Published —
This study tested the safety and efficacy of using transdermal estradiol for prevention of androgen toxicity in patients with prostate cancer.
  • Condition: Advanced Prostate Cancer
  • Journal: Zhonghua nan ke xue = National journal of andrology
  • Treatment Used: Family-Centered Psychological Support
  • Number of Patients: 78
  • Published —
The study researched the outcomes of family-centered psychological support for patients with advanced prostate cancer.
Clinical Trial
  • Status: Not yet recruiting
  • Phase: Phase 3
  • Intervention Type: Drug
  • Participants: 250
  • Start Date: February 22, 2021
CATCH-R: A Rollover Study to Provide Continued Access to Clinical Therapy With Rucaparib