Raphael Schiffmann is a Neurologist in Dallas, Texas. Dr. Schiffmann has been practicing medicine for over 46 years and is rated as a Distinguished provider by MediFind in the treatment of Farber Lipogranulomatosis. His top areas of expertise are Gaucher Disease Type 3, Fabry Disease, Gaucher Disease, and Leukodystrophy.

Vikram Shakkottai is a Neurologist in Dallas, Texas. Dr. Shakkottai is rated as a Distinguished provider by MediFind in the treatment of Farber Lipogranulomatosis. His top areas of expertise are Olivopontocerebellar Atrophy, Spinocerebellar Ataxia, Spinocerebellar Ataxia Type 1, and Drug Induced Dyskinesia.

Rafael Villalobos is a Neurologist in Brownsville, Texas. Dr. Villalobos is rated as an Experienced provider by MediFind in the treatment of Farber Lipogranulomatosis. His top areas of expertise are Susac Syndrome, GAPO Syndrome, Autism Spectrum Disorder, and Delayed Growth.

Michelle Christie is a Neurologist in Dallas, Texas. Dr. Christie is rated as an Experienced provider by MediFind in the treatment of Farber Lipogranulomatosis. Her top areas of expertise are Spastic Paraplegia Type 7, Spastic Paraplegia Type 2, Cerebral Palsy, and Paraplegia.

Arun Nagaraj is a Neurologist and a Cardiac Electrophysiologist in Dallas, Texas. Dr. Nagaraj has been practicing medicine for over 15 years and is rated as an Experienced provider by MediFind in the treatment of Farber Lipogranulomatosis. His top areas of expertise are Multiple Sclerosis (MS), Relapsing Multiple Sclerosis (RMS), Peripheral Neuropathy, and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.

Saima Kayani is a Pediatric Neurologist and a Pediatrics provider in Dallas, Texas. Dr. Kayani is rated as an Advanced provider by MediFind in the treatment of Farber Lipogranulomatosis. Her top areas of expertise are Leigh Syndrome, Batten Disease, CLN3 Disease, and CLN5 Disease.

Jinfon Ong is a Pediatric Neurologist and a Neurologist in Austin, Texas. Dr. Ong is rated as an Advanced provider by MediFind in the treatment of Farber Lipogranulomatosis. His top areas of expertise are Cerebral Palsy, GAPO Syndrome, Cerebral Arteriovenous Malformation, and Canavan Disease. Dr. Ong is currently accepting new patients.

Firoozeh Kar is a primary care provider, practicing in Internal Medicine in Webster, Texas. Dr. Kar is rated as an Advanced provider by MediFind in the treatment of Farber Lipogranulomatosis. Her top areas of expertise are Cellulitis, Muscle Atrophy, End-Stage Renal Disease (ESRD), and Dementia. Dr. Kar is currently accepting new patients.

Recent advances have made the discovery of genetic susceptibility loci for complex human phenotypes a reality, including nervous system disorders. The critical next step will be to definitively identify the responsible genes and understand their functions in both health and disease. Our research integrates genetic investigation in human subjects and model organisms, with the goal of understanding brain function and aging, and improving the treatment of neurologic disease. We focus on Alzheimer's disease and Parkinson's disease, two incurable neurodegenerative disorders and experimental paradigms for the age-dependent failure of brain cognitive and motor control in humans. Human Genetics: The clinical manifestation of neurodegenerative disease is the culmination of a multi-tiered pathogenic cascade that evolves over decades; understanding how genetic variants impact this causal chain is essential. Although 2 percent of the population over age 65 are clinically diagnosed with Parkinson's disease, the defining pathology of disease (alpha-synuclein Lewy bodies) is discovered in 20 percent of brains from population-based autopsy studies. We are, therefore, investigating the impact of genomic variation on directly measured Lewy pathology, neuronal loss in the midbrain substantia nigra, and progressive motor impairment, leveraging human subject cohorts with detailed clinical and pathological data. In complementary investigations, we are deploying biosensor devices to improve detection of Parkinson's-related motor impairment, including the development of quantitative biometric phenotypes for genetic analyses of disease subtypes. We are also performing whole exome sequencing of individuals with familial Parkinson's disease and related disorders, and exploring potential links between inherited pediatric lysosomal and late-onset, adult neurodegenerative diseases. Drosophila Genetics: Despite the promise of current human genetic methods, such as genome-wide association studies and next generation sequencing, they often fail to definitively identify disease susceptibility genes and variants. We are, therefore, taking advantage of the rapid and powerful genetics available in the fruit fly Drosophila melanogaster in order to accelerate the validation of responsible genes and an understanding of their functions in the nervous system, including for disease pathogenesis. Expression of human amyloid-beta, Tau, or alpha-synuclein proteins in the fly nervous system recapitulates many core features of Alzheimer's disease and Parkinson's disease pathogenesis. We are testing candidate human susceptibility genes for functional genetic interactions in these fly models of neurodegeneration. Implicated molecular pathways are probed in greater depth, using both Drosophila and human genetic approaches. Current areas of interest include endolysosomal sorting, RNA metabolism/splicing, neuronal cell adhesion, and synaptic mechanisms of neurodegeneration. Dr. Shulman is rated as an Experienced provider by MediFind in the treatment of Farber Lipogranulomatosis. His top areas of expertise are Parkinson's Disease, Movement Disorders, Alzheimer's Disease, and Dementia.

Holly Keeley is a Pediatric Neurologist and a Pediatrics provider in Austin, Texas. Dr. Keeley is rated as an Experienced provider by MediFind in the treatment of Farber Lipogranulomatosis. Her top areas of expertise are GAPO Syndrome, Cerebral Palsy, Delayed Growth, and Alexander Disease.

Karen Keough is a Pediatrics specialist and a Pediatric Neurologist in Austin, Texas. Dr. Keough is rated as an Experienced provider by MediFind in the treatment of Farber Lipogranulomatosis. Her top areas of expertise are Lennox-Gastaut Syndrome (LGS), Seizures, Autosomal Dominant Nocturnal Frontal Lobe Epilepsy (ADNFLE), and Lissencephaly 1. Dr. Keough is currently accepting new patients.

Jennifer Thomas is a Pediatric Neurologist and a Pediatrics provider in Dallas, Texas. Dr. Thomas is rated as an Experienced provider by MediFind in the treatment of Farber Lipogranulomatosis. Her top areas of expertise are Aphantasia, GAPO Syndrome, Lissencephaly, and Cerebellar Agenesis.

Brendan Kelley is a Neurologist in Dallas, Texas. Dr. Kelley is rated as an Experienced provider by MediFind in the treatment of Farber Lipogranulomatosis. His top areas of expertise are Lewy Body Dementia (LBD), Cerebellar Degeneration, Neuronal Intranuclear Inclusion Disease (NIID), and Primary Progressive Aphasia.

Sarah Elsea is a Medical Genetics provider in Houston, Texas. Dr. Elsea is rated as an Experienced provider by MediFind in the treatment of Farber Lipogranulomatosis. Her top areas of expertise are Smith-Magenis Syndrome, Potocki-Lupski Syndrome, Hypotonia, and Zellweger Syndrome.

Qin Huang is a primary care provider, practicing in Internal Medicine in Tyler, Texas. Dr. Huang is rated as an Experienced provider by MediFind in the treatment of Farber Lipogranulomatosis. His top areas of expertise are Stroke, Atypical Pneumonia, Peptic Ulcer, Endoscopy, and Gastrostomy. Dr. Huang is currently accepting new patients.

Robin Hougen is a Pediatric Neurologist and a Pediatrics provider in Corpus Christi, Texas. Dr. Hougen is rated as an Experienced provider by MediFind in the treatment of Farber Lipogranulomatosis. Her top areas of expertise are Tourette Syndrome, Progressive Myoclonic Epilepsy, Lafora Disease, and Unverricht-Lundborg Syndrome. Dr. Hougen is currently accepting new patients.

Sharon Nations is a Neurologist in Dallas, Texas. Dr. Nations is rated as an Experienced provider by MediFind in the treatment of Farber Lipogranulomatosis. Her top areas of expertise are Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease), Myasthenia Gravis, Spinal Muscular Atrophy (SMA), Stiff Person Syndrome, and Thymectomy.

Leonardo Garcia-Mendez is a Pediatric Neurologist and a Sleep Medicine provider in Mcallen, Texas. Dr. Garcia-Mendez is rated as an Experienced provider by MediFind in the treatment of Farber Lipogranulomatosis. His top areas of expertise are Increased Head Circumference, Autosomal Dominant Partial Epilepsy with Auditory Features, Zika Virus Disease, and Microcephaly. Dr. Garcia-Mendez is currently accepting new patients.

Kendra Beneski is a Pediatric Neurologist and a Neurologist in Plano, Texas. Dr. Beneski is rated as an Experienced provider by MediFind in the treatment of Farber Lipogranulomatosis. Her top areas of expertise are Seizures, Memory Loss, Aphantasia, and Benign Rolandic Epilepsy. Dr. Beneski is currently accepting new patients.

Lindsay Horton is a Neurologist in Dallas, Texas. Dr. Horton is rated as an Experienced provider by MediFind in the treatment of Farber Lipogranulomatosis. Her top areas of expertise are Relapsing Multiple Sclerosis (RMS), Multiple Sclerosis (MS), Transverse Myelitis, and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.