Learn About Felty Syndrome

What is the definition of Felty Syndrome?

Felty syndrome is a disorder that includes rheumatoid arthritis, a swollen spleen, decreased white blood cell count, and repeated infections. It is rare.

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What are the alternative names for Felty Syndrome?

Seropositive rheumatoid arthritis (RA); Felty's syndrome

What are the causes of Felty Syndrome?

The cause of Felty syndrome is unknown. It is more common in people who have had rheumatoid arthritis (RA) for a long time. People with this syndrome are at risk for infection because they have a low white blood cell count.

What are the symptoms of Felty Syndrome?

Symptoms include:

  • General feeling of discomfort (malaise)
  • Fatigue
  • Weakness in leg or arm
  • Loss of appetite
  • Unintentional weight loss
  • Ulcers in the skin
  • Joint swelling, stiffness, pain, and deformity
  • Recurrent infections
  • Red eye with burning or discharge
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What are the current treatments for Felty Syndrome?

In most cases, people who have this syndrome are not getting recommended treatment for RA. They may need other medicines to suppress their immune system and reduce the activity of their RA.

Methotrexate may improve the low neutrophil count. The drug rituximab has been successful in people who do not respond to methotrexate.

Granulocyte-colony stimulating factor (G-CSF) may raise the neutrophil count.

Some people benefit from removal of the spleen (splenectomy).

Who are the top Felty Syndrome Local Doctors?
Distinguished
Highly rated in
13
conditions
Oncology
Hematology Oncology
Hematology

UVA Health System

Emily Couric Clinical Cancer Center

1240 Lee St 
Charlottesville, VA 22908

Thomas Loughran is an Oncologist and a Hematologist Oncology doctor in Charlottesville, Virginia. Dr. Loughran has been practicing medicine for over 43 years and is rated as a Distinguished doctor by MediFind in the treatment of Felty Syndrome. He is also highly rated in 13 other conditions, according to our data. His top areas of expertise are Adult T-Cell Leukemia, Felty Syndrome, Leukemia, and Chronic T-Cell Leukemia. He is licensed to treat patients in Pennsylvania and Virginia. Dr. Loughran is currently accepting new patients.

Distinguished
Highly rated in
11
conditions

V.A. Nasonova Research Institute Of Rheumatology

Department Of Intensive Methods Of Therapy 
Moscow, MOW, RU 

Vadim Gorodetskiy is in Moscow, Russian Federation. Gorodetskiy is rated as a Distinguished expert by MediFind in the treatment of Felty Syndrome. He is also highly rated in 11 other conditions, according to our data. His top areas of expertise are Felty Syndrome, Sjogren Syndrome, Dry Mouth, and Diffuse Large B-Cell Lymphoma DLBCL.

 
 
 
 
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Distinguished
Highly rated in
41
conditions
Oncology
Hematology Oncology

Archbold Medical Center

Lewis Hall Singletary Oncology Center

919 S Broad St 
Thomasville, GA 31792

Amanda May is an Oncologist and a Hematologist Oncology doctor in Thomasville, Georgia. Dr. May has been practicing medicine for over 25 years and is rated as a Distinguished doctor by MediFind in the treatment of Felty Syndrome. She is also highly rated in 41 other conditions, according to our data. Her top areas of expertise are Felty Syndrome, Pleuropulmonary Blastoma, Lung Cancer, and Paget Disease of the Breast. She is licensed to treat patients in Georgia. Dr. May is currently accepting new patients.

What is the outlook (prognosis) for Felty Syndrome?

Without treatment, infections may continue to occur.

RA is likely to get worse.

Treating the RA, however, should improve Felty syndrome.

What are the possible complications of Felty Syndrome?

You may have infections that keep coming back.

Some people with Felty syndrome have increased numbers of large granular lymphocytes, also called LGL leukemia. This will be treated with methotrexate in many cases.

When should I contact a medical professional for Felty Syndrome?

Call your health care provider if you develop symptoms of this disorder.

How do I prevent Felty Syndrome?

Prompt treatment of RA with currently recommended medicines markedly decreases the risk of developing Felty syndrome.

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What are the Latest Advances for Felty Syndrome?
Tocilizumab treatment in Felty's syndrome.
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Who are the sources who wrote this article ?

Published Date : May 02, 2021
Published By : Diane M. Horowitz, MD, Rheumatology and Internal Medicine, Northwell Health, Great Neck, NY. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Andolfi C, Fisichella MP. Splenectomy for hematologic disorders. In: Cameron AM, Cameron JL, eds. Current Surgical Therapy. 13th ed. Philadelphia, PA: Elsevier; 2020:605-612.

England BR, Mikuls TR. Clinical features of rheumatoid arthritis. In: Firestein GS, Budd RC, Gabriel SE, Koretzky GA, McInnes IB, O'Dell JR, eds. Firestein & Kelley's Textbook of Rheumatology. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 76.

Gazitt T, Loughran TP Jr. Chronic neutropenia in LGL leukemia and rheumatoid arthritis. Hematology Am Soc Hematol Educ Program. 2017;2017(1):181-186. PMID: 29222254 pubmed.ncbi.nlm.nih.gov/29222254/.

Myasoedova E, Turesson C, Matteson EL. Extraarticular features of rheumatoid arthritis. In: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, eds. Rheumatology. 7th ed. Philadelphia, PA: Elsevier; 2019:chap 95.

Savola P, Brück O, Olson T, et al. Somatic STAT3 mutations in Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia. Haematologica. 2018;103(2):304-312. PMID: 29217783 pubmed.ncbi.nlm.nih.gov/29217783/.

Wang CR, Chiu YC, Chen YC. Successful treatment of refractory neutropenia in Felty's syndrome with rituximab. Scand J Rheumatol. 2018;47(4):340-341. PMID: 28753121 pubmed.ncbi.nlm.nih.gov/28753121/.