Fibrolamellar Carcinoma
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Learn About Fibrolamellar Carcinoma

What is the definition of Fibrolamellar Carcinoma?
Many people with early FLC have no signs or symptoms of the condition. When present, symptoms are often nonspecific (i.e. abdominal pain, weight loss, malaise) and blamed on other, more common conditions. The exact underlying cause of FLC is poorly understood. Unlike other forms of liver cancer, FLC typically occurs in the absence of underlying liver inflammation or scarring; thus, specific risk factors for this condition remain unidentified.
What are the alternative names for Fibrolamellar Carcinoma?
  • Fibrolamellar carcinoma
  • Eosinophilic glassy cell hepatoma
  • Eosinophilic hepatocellular carcinoma with lamellar fibrosis
  • FHCC
  • FL-HCC
  • Fibrolamellar hepatocarcinoma
  • Fibrolamellar hepatocellular carcinoma
  • Fibrolamellar oncocytic hepatoma
  • Hepatocellular carcinoma with increased stromal fibrosis
  • Polygonal cell hepatocellular carcinoma with fibrous stroma
Who are the top Fibrolamellar Carcinoma Local Doctors?
Elite in Fibrolamellar Carcinoma
Elite in Fibrolamellar Carcinoma
Referral may be required

Skip Viragh Outpatient Cancer Center

201 North Broadway Street, Viragh BLDG 5th FL, Viragh BLDG 5th FL, 
Baltimore, MD 
Languages Spoken:
English, French, Italian, Spanish
Offers Telehealth

Marina Baretti, MD, is an assistant professor at Johns Hopkins University School of Medicine and the Jiasheng Chair in Hepato-Biliary Cancer Research. She also serves as Co-Director of the Liver and Biliary Cancer Multidisciplinary Clinic at the Sidney Kimmel Comprehensive Cancer Center (SKCCC). Dr. Baretti received her medical degree from the University of Pisa in Italy. She completed her internal medicine residency and oncology fellowship at University of Milan. She then went on and completed her Postdoctoral and Medical Oncology Fellowship at Johns Hopkins University, Baltimore, Maryland. She is deeply engaged in bridging the gap between laboratory discoveries and clinical application, working closely with laboratory-based scientists to accelerate the development of novel therapeutic strategies. Her academic research is centered on the development of novel agents in hepatobiliary cancers, with particular interest in combinatorial approaches of immunotherapies. She is currently the principal investigator on multiple clinical trials in FLC, HCC and cholangiocarcinoma at Johns Hopkins University, collaborating closely with laboratory-based researchers to move laboratory findings into patients. Through her work, Dr. Baretti strives to improve outcomes for patients with rare GI cancers by identifying innovative therapies that are informed by a deeper understanding of tumor biology and the tumor microenvironment. Dr. Baretti was the recipient of the 2018 American Society of Clinical Oncology Young Investigator Award. Dr. Baretti was also awarded with the 2020 Career Development Award for the MD Anderson Cancer Center’s pancreatic cancer NCI Specialized Programs of Research Excellence (SPORE). Dr. Baretti is rated as an Elite provider by MediFind in the treatment of Fibrolamellar Carcinoma. She is also highly rated in 4 other conditions, according to our data. Her clinical expertise encompasses Fibrolamellar Carcinoma, Cholangiocarcinoma (Bile Duct Cancer), Liver Cancer, and Pancreatic Cancer.

Distinguished in Fibrolamellar Carcinoma
General Surgery
Distinguished in Fibrolamellar Carcinoma
General Surgery
Referral may be required

ETSU Physicians & Associates- Surgery

325 N State Of Franklin Rd, 
Johnson City, TN 
Languages Spoken:
English
Offers Telehealth

Joseph Lee is a General Surgeon practicing medicine in Johnson City, Tennessee. Dr. Lee is rated as a Distinguished provider by MediFind in the treatment of Fibrolamellar Carcinoma. He is also highly rated in 19 other conditions, according to our data. His clinical expertise encompasses Fibrolamellar Carcinoma, Familial Pancreatic Cancer, Pancreatic Cancer, Pancreatectomy, and Small Bowel Resection. Dr. Lee is board certified in American Board Of Surgery.

 
 
 
 
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Distinguished in Fibrolamellar Carcinoma
Distinguished in Fibrolamellar Carcinoma
Referral may be required

Hospital Of The University Of Pennsylvania Radiology

3400 Spruce Street, 
Philadelphia, PA 
Languages Spoken:
English
Offers Telehealth

Gregory Nadolski is a Radiologist practicing medicine in Philadelphia, Pennsylvania. Dr. Nadolski is rated as a Distinguished provider by MediFind in the treatment of Fibrolamellar Carcinoma. He is also highly rated in 12 other conditions, according to our data. His clinical expertise encompasses Chylous Ascites, Kimura Disease, Fibrolamellar Carcinoma, Liver Embolization, and Gastrostomy. Dr. Nadolski is board certified in American Board Of Radiology.

What are the latest Fibrolamellar Carcinoma Clinical Trials?
DT2216 in Combination With Irinotecan for Children, Adolescents and Young Adults With Relapsed or Refractory Solid Tumors: A Phase I Study With Phase II Feasibility Cohort for Fibrolamellar Carcinoma

Summary: This phase I/II trial tests the safety, side effects and best dose of DT2216 in combination with irinotecan and how well it works in treating children, adolescents and young adults with solid tumors and fibrolamellar cancer that has come back after a period of improvement (relapsed) or that has not responded to previous treatment (refractory). DT2216 is an anti-apoptotic protein B-cell lymphoma-ex...

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A Phase I/II Study of Nivolumab Plus 5-Fluorouracil Plus Interferon-α2b for Unresectable Fibrolamellar Hepatocellular Carcinoma

Summary: This phase I/II trial studies the side effects and how well nivolumab, fluorouracil, and interferon alpha 2b work for the treatment of fibrolamellar cancer (liver cell cancer) that cannot be removed by surgery (unresectable). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer and may interfere with the ability of tumor cells to grow and...

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center