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Learn About Fibrolamellar Carcinoma

What is the definition of Fibrolamellar Carcinoma?
Many people with early FLC have no signs or symptoms of the condition. When present, symptoms are often nonspecific (i.e. abdominal pain, weight loss, malaise) and blamed on other, more common conditions. The exact underlying cause of FLC is poorly understood. Unlike other forms of liver cancer, FLC typically occurs in the absence of underlying liver inflammation or scarring; thus, specific risk factors for this condition remain unidentified.
What are the alternative names for Fibrolamellar Carcinoma?
  • Fibrolamellar carcinoma
  • Eosinophilic glassy cell hepatoma
  • Eosinophilic hepatocellular carcinoma with lamellar fibrosis
  • FHCC
  • FL-HCC
  • Fibrolamellar hepatocarcinoma
  • Fibrolamellar hepatocellular carcinoma
  • Fibrolamellar oncocytic hepatoma
  • Hepatocellular carcinoma with increased stromal fibrosis
  • Polygonal cell hepatocellular carcinoma with fibrous stroma
Who are the top Fibrolamellar Carcinoma Local Doctors?

MD Anderson

2130 W Holcombe Blvd, Life Sciences Plaza, 
Houston, TX 
Offers Telehealth

Ahmed Kaseb is an Oncologist in Houston, Texas. Dr. Kaseb and is rated as an Elite provider by MediFind in the treatment of Fibrolamellar Carcinoma. His top areas of expertise are Liver Cancer, Fibrolamellar Carcinoma, Cholangiocarcinoma (Bile Duct Cancer), Hepatectomy, and Liver Embolization.

Family Medicine
Family Medicine
6805 Hunter Run Place, 
Prospect, KY 

Sanford Simon is a Family Medicine provider in Prospect, Kentucky. Dr. Simon and is rated as an Elite provider by MediFind in the treatment of Fibrolamellar Carcinoma. His top areas of expertise are Fibrolamellar Carcinoma, Liver Cancer, Angiosarcoma of the Liver, and HIV/AIDS.

 
 
 
 
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Johns Hopkins University

5755 Cedar Ln, 
Columbia, MD 
Offers Telehealth

Mark Yarchoan is an Oncologist in Columbia, Maryland. Dr. Yarchoan and is rated as an Elite provider by MediFind in the treatment of Fibrolamellar Carcinoma. His top areas of expertise are Fibrolamellar Carcinoma, Cholangiocarcinoma (Bile Duct Cancer), Liver Cancer, Pancreatic Cancer, and Hepatectomy.

What are the latest Fibrolamellar Carcinoma Clinical Trials?
FusionVAC22_01: DNAJB1-PRKACA Fusion Transcript-based Peptide Vaccine Combined with Immune Checkpoint Inhibition for Fibrolamellar Hepatocellular Carcinoma and Other Tumor Entities Carrying the Oncogenic Driver Fusion

Summary: The aim of this clinical trial is to evaluate the immunogenicity along with safety and toxicity as well as first efficacy of a DNAJB1-PRKACA fusion transcript-based peptide vaccine (Fusion-VAC-XS15) in combination with anti-programmed cell death-ligand 1 immune checkpoint inhibition (ICI) by Atezolizumab (TecentriqTM) in patients with Fibrolamellar hepatocellular carcinoma (FL-HCC) or other cancer...

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A Phase 1b/2 Study of Glutamine Antagonist DRP-104 in Combination With Durvalumab in Patients With Advanced Stage Fibrolamellar Hepatocellular Carcinoma (FLC)

Summary: The purpose of this study is to determine whether the combination of subcutaneous DRP-104 in combination with intravenous Durvalumab is safe and yields a clinically compelling antitumor activity measured as based on objective response rate (ORR, assessed by RECIST 1.1). Secondary objectives include progression-free survival (PFS) and overall survival (OS).

Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center