Supraspinal Processing of Sensory Aspects of Pain

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this basic science study is to learn about the brain mechanisms of chronic pain across different chronic pain syndromes in pediatric patients. The main questions it aims to answer are: * Are there shared and distinct brain systems engaged by different forms of pediatric chronic pain? * What are predictors of recovery from chronic pain? * What brain systems are associated with the spread of pain? For this study participants will undergo: * Functional Magnetic Resonance Imaging (fMRI) * Quantitative Sensory Testing * Psychological Assessments

Eligibility
Participation Requirements
Sex: All
Minimum Age: 10
Maximum Age: 17
Healthy Volunteers: t
View:

• Patients will need a diagnosis of a chronic pain derived congruent with ICD-11 criteria related to headache (migraine, daily headache), abdominal (FAPD), localized MSK (single limb/joint, low back or chest pain), diffuse MSK (widespread MSK pain), or CRPS

• If on medications, they need to be on stable doses of prescribed pain and/or psychiatric medications for 4 weeks before the baseline study visit.

• Male or female, age 10 -17 (inclusive)

• English speaking, able to complete interviews and questionnaires in English

Locations
United States
Ohio
Cincinnati Children's Hospital
RECRUITING
Cincinnati
Contact Information
Primary
Catherine Jackson, MSc
Catherine.Jackson@cchmc.org
5136360669
Backup
Hannah Schildmeyer, BS
Hannah.Schildmeyer@cchmc.org
Time Frame
Start Date: 2023-05-01
Estimated Completion Date: 2027-06-30
Participants
Target number of participants: 350
Treatments
Experimental: Healthy Controls
Healthy controls with no history of chronic pain.
Experimental: Headache and Migraine
Individuals who have migraine with headaches.
Experimental: Functional Abdominal Pain Disorder (FAPD)
Individuals who have functional abdominal pain disorder.
Experimental: Localized and Diffuse/Widespread Musculoskeletal Pain (MSK)
Individuals with chronic musculoskeletal pain.
Experimental: Complex Regional Pain Syndrome (CRPS)
Individuals with complex regional pain syndrome.
Sponsors
Leads: Children's Hospital Medical Center, Cincinnati
Collaborators: University of Barcelona

This content was sourced from clinicaltrials.gov