Learn About Fish-Eye Disease
Fish-eye disease, also called partial LCAT deficiency, is a disorder that causes the clear front surface of the eyes (the corneas) to gradually become cloudy. The cloudiness, which generally first appears in adolescence or early adulthood, consists of small grayish dots of cholesterol (opacities) distributed across the corneas. Cholesterol is a waxy, fat-like substance that is produced in the body and obtained from foods that come from animals; it aids in many functions of the body but can become harmful in excessive amounts. As fish-eye disease progresses, the corneal cloudiness worsens and can lead to severely impaired vision.
Fish-eye disease is caused by mutations in the LCAT gene. This gene provides instructions for making an enzyme called lecithin-cholesterol acyltransferase (LCAT).
Fish-eye disease is a rare disorder. Approximately 30 cases have been reported in the medical literature.
This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.
Texas Health Family Care
Richard Townsend is a primary care provider, practicing in General Practice in Richardson, Texas. Dr. Townsend is rated as an Advanced provider by MediFind in the treatment of Fish-Eye Disease. His top areas of expertise are Vitamin D Deficiency, Gilbert Syndrome, High Cholesterol, and Nephrosclerosis.
Texas Health Family Care
Karna Gocke is a primary care provider, practicing in Family Medicine in Prosper, Texas. Dr. Gocke is rated as an Advanced provider by MediFind in the treatment of Fish-Eye Disease. Her top areas of expertise are Vitamin D Deficiency, Peripheral Neuropathy, Familial Hypertriglyceridemia, Obesity, and Intrauterine Device Insertion.
Texas Health Family Care
Emily Jones is a primary care provider, practicing in Family Medicine in Richardson, Texas. Dr. Jones is rated as an Advanced provider by MediFind in the treatment of Fish-Eye Disease. Her top areas of expertise are Obesity, Familial Hypobetalipoproteinemia, Familial HDL Deficiency, and Fish-Eye Disease.
Summary: The purpose of the LCAT (Lecithin cholesterol acyl transferase) Natural History Study (LCAT NHS) is to help identify people with a mutation in a gene called LCAT, collect and store information about their medical history and disease course, and to assess for associations and follow changes in clinical features and biomarkers of disease. This information will help health care providers better under...
Published Date: August 01, 2013
Published By: National Institutes of Health