A Multicenter, Prospective, Real World Study of Rituximab in Frontline Therapy for Glomerulonephritis

Status: Recruiting
Location: See all (5) locations...
Study Type: Observational
SUMMARY

This study included patients with glomerulonephritis who planned to receive rituximab treatment, and observed the efficacy and safety of rituximab in different glomerulonephritis in the real world. According to the pathological types of glomerulonephritis, they were divided into two cohorts : membranous nephropathy ( MN ) group or minimal change disease / focal segmental glomerulosclerosis ( MCD / FSGS ) group.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
View:

• Primary MN, MCD/FSGS patients confirmed by biopsy

• Consistent with nephrotic syndrome ( urinary protein\>3.5g/d and serum albumin\< 30g/L), and the researchers consider that immunosuppressive therapy is needed

• Estimated glomerular filtration rate ( eGFR≥60 ml/min/1.73m2 )

• Patients providing written informed consent before initiation of any study-related activities

Locations
Other Locations
China
Changhai Hospital
NOT_YET_RECRUITING
Shanghai
Renji Hospital, Shanghai Jiao Tong University School of Medicine
NOT_YET_RECRUITING
Shanghai
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
NOT_YET_RECRUITING
Shanghai
Shanghai 6th People's Hospital
NOT_YET_RECRUITING
Shanghai
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
RECRUITING
Shanghai
Contact Information
Primary
GENGRU JIANG, doctor
jianggengru@xinhuamed.com.cn
+86-13816238339
Time Frame
Start Date: 2023-02-01
Estimated Completion Date: 2025-12-01
Participants
Target number of participants: 100
Treatments
cohort A
pathologically confirmed membranous nephropathy
cohort B
pathologically confirmed minimal change disease (MCD) or primary focal segmental glomerulosclerosis (FSGS)
Sponsors
Leads: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

This content was sourced from clinicaltrials.gov