MediFind
Condition

Minimal Change Disease

Symptoms, Doctors, Treatments, Research & More

Condition 101

What is the definition of Minimal Change Disease?

Minimal change disease is a kidney disorder that can lead to nephrotic syndrome. Nephrotic syndrome is a group of symptoms that include protein in the urine, low blood protein levels in the blood, high cholesterol levels, high triglyceride levels, and swelling.

What are the alternative names for Minimal Change Disease?

Minimal change nephrotic syndrome; Nil disease; Lipoid nephrosis; Idiopathic nephrotic syndrome of childhood

What are the causes for Minimal Change Disease?

Each kidney is made of more than a million units called nephrons, which filter blood and produce urine.

In minimal change disease, there is damage to the glomeruli. These are the tiny blood vessels inside the nephron where blood is filtered to make urine and waste is removed. The disease gets its name because this damage is not visible under a regular microscope. It can only be seen under a very powerful microscope called an electron microscope.

Minimal change disease is the most common cause of nephrotic syndrome in children. It is also seen in adults with nephrotic syndrome, but is less common.

The cause is unknown, but the disease may occur after or be related to:

  • Allergic reactions
  • Use of NSAIDs
  • Tumors
  • Vaccinations (flu and pneumococcal, though rare)
  • Viral infections

What are the symptoms for Minimal Change Disease?

There may be symptoms of nephrotic syndrome, including:

  • Foamy appearance of the urine
  • Poor appetite
  • Swelling (especially around the eyes, feet, and ankles, and in the abdomen)
  • Weight gain (from fluid retention)

Minimal change disease does not reduce the amount of urine produced. It rarely progresses to kidney failure.

What are the current treatments for Minimal Change Disease?

Medicines called corticosteroids can cure minimal change disease in most children. Some children may need to stay on steroids to keep the disease from returning.

Steroids are effective in adults, but less so in children. Adults may have more frequent relapses and become dependent on steroids.

If steroids are not effective, the provider will likely suggest other medicines.

Swelling may be treated with:

  • ACE inhibitor medicines
  • Blood pressure control
  • Diuretics (water pills)

You may also be told to reduce the amount of salt in your diet.

What is the outlook (prognosis) for Minimal Change Disease?

Children usually respond better to corticosteroids than adults. Children often respond within the first month.

A relapse can occur. The condition may improve after long-term treatment with corticosteroids and medicines that suppress the immune system (immunosuppressants).

When should I contact a medical professional for Minimal Change Disease?

Call your provider if:

  • You develop symptoms of minimal change disease
  • You have this disorder and your symptoms get worse
  • You develop new symptoms, including side effects from the medicines used to treat the disorder
Glomerulus

REFERENCES

Appel GB, Radhakrishnan J, D'Agati VD. Secondary glomerular disease. In: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner and Rector's The Kidney. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 32.

Erkan E. Nephrotic syndrome. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 545.

Latest Research

Latest Advance
Study
  • Condition: Cancer
  • Journal: Journal for immunotherapy of cancer
  • Treatment Used: Immune Checkpoint Inhibitor Therapy
  • Number of Patients: 309
  • Published —
The study researched the safety of immune checkpoint inhibitor therapy.
Latest Advance
Study
  • Condition: De Novo Minimal Change Disease
  • Journal: Clinical journal of the American Society of Nephrology : CJASN
  • Treatment Used: Tacrolimus and Prednisolone Monotherapy
  • Number of Patients: 50
  • Published —
The study researched the outcomes of Tacrolimus and Prednisolone alone for De Novo minimal change disease.