A Feasibility Trial of Tazemetostat Plus CAR T Cell Therapy in B-cell Lymphomas

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 1
SUMMARY

This is a clinical trial to evaluate the feasibility and safety of giving tazemetostat followed by standard of care CAR T cell infusion in previously treated diffuse large b-cell lymphoma (DLBCL), follicular lymphoma (FL), and mantle cell lymphoma (MCL). The investigators hypothesis is that this combination has the potential to significantly improve the ability of CART cells to recognize and kill lymphoma cells without a significant impact on safety. Participants will receive the tazemetostat pills before and after receiving their CAR T cell therapy, for up to 12 months after CAR T cell administration. Patients will be followed for up to 5 years.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Confirmed diagnosis of DLBCL, FL, or MCL

• Eligible to receive standard of care CAR T cells

• Have received at least 1 prior therapies

Locations
United States
New York
Weill Cornell Medicine/NewYork-Presbyterian Hospital
RECRUITING
New York
Contact Information
Primary
Nicole Santos
nis7058@med.cornell.edu
646-962-6827
Backup
Samuel Yamshon, MD
sjy9001@med.cornell.edu
646-962-7950
Time Frame
Start Date: 2023-10-04
Estimated Completion Date: 2031-09
Participants
Target number of participants: 15
Treatments
Experimental: Tazemetostat and CAR T-Cell Therapy
Tazemetostat is being administered prior to, and following, standard of care CAR T cell therapy. The use of tazemetostat in this way is investigational.
Sponsors
Collaborators: American Society of Clinical Oncology, Epizyme, Inc., Applebaum Foundation
Leads: Weill Medical College of Cornell University

This content was sourced from clinicaltrials.gov