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Transcutaneous Electrical Acupoint Stimulation Combined With Triple Antiemetic Drugs for Postoperative Nausea and Vomiting in High-Risk Patients: A Multicenter Randomized Controlled Trial

Status: Recruiting
Location: See location...
Intervention Type: Device, Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to evaluate the effects of transcutaneous electrical acupoint stimulation (TEAS) combined with triple antiemetics for postoperative nausea and vomiting (PONV) in high-risk patients. The primary question it seeks to answer is: Does TEAS combined with triple antiemetics further reduce the incidence of PONV in high-risk subjects? Researchers will compare active TEAS with sham stimulation to determine whether the addition of TEAS to dexamethasone, palonosetron, and droperidol lowers the PONV rate beyond that achieved by the triple-drug prophylaxis alone.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:

• Women scheduled for laparoscopic surgery ;

• Aged 18-65 years;

• ASA Class I-III;

• Apfel score ≥ 3 (female sex, non-smoker, history of PONV and/or motion sickness).

Locations
Other Locations
China
The First Affiliated Hospital, Zhejiang University School of Medicine
RECRUITING
Hangzhou
Contact Information
Primary
Diansan Su, PhD
diansansu@yahoo.com
+8618616514088
Backup
Dongdong Tian
tddcomeon@163.com
+8615924165551
Time Frame
Start Date: 2026-01-16
Estimated Completion Date: 2027-10-31
Participants
Target number of participants: 780
Treatments
Experimental: The TEAS group
The TEAS group,Nei-guan (PC6) and He-gu (LI4) were stimulated by a transcutaneous acupoint electrical stimulation instrument approximately 30 minutes before anesthesia induction until the patient is discharged from the operating room.
Sham_comparator: The control group
The same protocol was applied for percutaneous acupoint electrical stimulation, initiated before anesthesia induction with the minimum perceptible current (MPC) and terminated after 1 minute. To ensure complete blinding, both groups were covered with opaque sheets over the percutaneous acupoint electrical stimulation device.
Sponsors
Collaborators: Jinhua Central Hospital, Huzhou Central Hospital, The First People's Hospital of Huzhou
Leads: Zhejiang University

This content was sourced from clinicaltrials.gov