Learn About Gardner Syndrome

What is the definition of Gardner Syndrome?
Gardner syndrome is a form of familial adenomatous polyposis (FAP) that is characterized by multiple colorectal polyps and various types of tumors, both benign (noncancerous) and malignant (cancerous). They are also at an increased risk of developing other FAP-related cancers, such as those of the small bowel, stomach, pancreas, thyroid, central nervous system, liver, bile ducts, and/or adrenal gland. Other signs and symptoms of Gardner syndrome include dental abnormalities; osteomas (benign bone growths); various skin abnormalities such as epidermoid cysts, fibromas (a benign tumor of the connective tissue), and lipomas; and desmoid tumors. It is caused by changes in the APC gene and inherited in an autosomal dominant manner. These may include high risk screening, prophylactic surgeries and/or certain types of medications.
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What are the alternative names for Gardner Syndrome?
  • Gardner syndrome
  • Gardner's syndrome
  • Intestinal polyposis, osteomas, sebaceous cysts
  • Polyposis coli and multiple hard and soft tissue tumors
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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center

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