Predictive Risk Factors for Postoperative Pancreatic Fistula After Pancreaticoduodenectomy for Malignancy.
Pancreaticoduodenectomy (PD) is a complex procedure performed in patients with malignant or benign tumors of the pancreatic head and periampullary region, associated with high morbidity and mortality. Postoperative pancreatic fistula (POPF) is the most common and clinically significant complication following PD. In this study, the investigators aim to determine the predictive risk factors for clinically related postoperative pancreatic fistula (CR-POPF) in the preoperative, intraoperative and postoperative period in patients that underwent PD. The total number of 100 participants expected to be included in this research who underwent PD between 2025 and 2026.
• Patients with resectable distal common bile duct carcinoma, periampullary carcinoma, duodenal carcinoma, and carcinoma of the head of the pancreas.
• Patients meeting the curative treatment intent in accordance with clinical guidelines:
‣ No evidence of metastasis.
⁃ Radiological non-involvement of superior mesenteric vein \& portal vein.
• American Society of Anesthesiologists (ASA) scores I \& II.
• Patients aged \> 18 years.
• Ability to understand and the willingness to sign a written informed consent document
• Agreement to complete the study