Gastrointestinal Stromal TumorSymptoms, Doctors, Treatments, Advances & More
Learn About Gastrointestinal Stromal Tumor
A gastrointestinal stromal tumor (GIST) is a type of tumor that occurs in the gastrointestinal tract, most commonly in the stomach or small intestine. This type of tumor is thought to grow from specialized cells found in the gastrointestinal tract called interstitial cells of Cajal (ICCs) or precursors to these cells. Affected individuals can develop one or more tumors. GISTs are usually found in adults between ages 40 and 70; rarely, children and young adults develop this type of tumor.
Genetic changes in one of several genes are involved in the formation of GISTs. About 80 percent of cases are associated with a mutation in the KIT gene, and about 10 percent of cases are associated with a mutation in the PDGFRA gene. Mutations in the KIT and PDGFRA genes are associated with both familial and sporadic GISTs. Less than 10 percent of cases are SDH-deficient GISTs, which are associated with mutations or other changes in the SDHA, SDHB, SDHC, or SDHD gene. SDH-deficient GIST can be familial or sporadic. A small number of people with a GIST have mutations in other genes.
Approximately 5,000 new cases of GIST are diagnosed in the United States each year. SDH-deficient GIST accounts for about 5 to 7 percent of cases. However, GISTs may be more common than the estimate because small tumors may remain undiagnosed.
Most cases of GIST are sporadic and are not inherited. These cases are associated with a somatic mutation, which is a genetic change that occurs only in the tumor cells and occurs during a person's lifetime.
Duke Cancer Center
Richard Riedel is an Oncologist practicing medicine in Durham, North Carolina. Dr. Riedel is rated as an Elite provider by MediFind in the treatment of Gastrointestinal Stromal Tumor. He is also highly rated in 30 other conditions, according to our data. His clinical expertise encompasses Adult Soft Tissue Sarcoma, Liposarcoma, Desmoid Tumor, and Angiosarcoma. Dr. Riedel is board certified in American Board Of Internal Med, Internal Medicine and American Board Of Internal Med, Medical Oncology. Dr. Riedel is currently accepting new patients.
Rockefeller Outpatient Pavilion
Mark Dickson is an Oncologist practicing medicine in New York, New York. Dr. Dickson is rated as an Elite provider by MediFind in the treatment of Gastrointestinal Stromal Tumor. He is also highly rated in 28 other conditions, according to our data. His clinical expertise encompasses Adult Soft Tissue Sarcoma, Liposarcoma, Undifferentiated Pleomorphic Sarcoma, Synovial Sarcoma, and Endoscopy. Dr. Dickson is currently accepting new patients.
UCSD Heath Care
Jason Sicklick is a General Surgeon practicing medicine in La Jolla, California. Dr. Sicklick is rated as an Elite provider by MediFind in the treatment of Gastrointestinal Stromal Tumor. He is also highly rated in 17 other conditions, according to our data. His clinical expertise encompasses Gastrointestinal Stromal Tumor, Adrenocortical Carcinoma, Adult Soft Tissue Sarcoma, Gallbladder Removal, and Gastrectomy.
Summary: The purpose of this study is to find out if a new drug, called IDRX-42 (also known as GSK6042981), is effective in treating adults with a type of cancer called Gastrointestinal Stromal Tumors (GIST) when compared to another drug named sunitinib. The study will see if IDRX-42 works well and is safe for participants whose GIST has spread or cannot be surgically removed, and who have already taken th...
Summary: This is a study to evaluate the efficacy and safety of belzutifan monotherapy in participants with advanced pheochromocytoma/paraganglioma (PPGL), pancreatic neuroendocrine tumor (pNET), von Hippel-Lindau (VHL) disease-associated tumors, advanced wt (wild-type) gastrointestinal stromal tumor (wt GIST), or advanced solid tumors with hypoxia inducible factor-2 alpha (HIF-2α) related genetic alterati...
Published Date: July 14, 2021
Published By: National Institutes of Health