Gastrointestinal Stromal TumorSymptoms, Doctors, Treatments, Advances & More
Learn About Gastrointestinal Stromal Tumor
A gastrointestinal stromal tumor (GIST) is a type of tumor that occurs in the gastrointestinal tract, most commonly in the stomach or small intestine. This type of tumor is thought to grow from specialized cells found in the gastrointestinal tract called interstitial cells of Cajal (ICCs) or precursors to these cells. Affected individuals can develop one or more tumors. GISTs are usually found in adults between ages 40 and 70; rarely, children and young adults develop this type of tumor.
Genetic changes in one of several genes are involved in the formation of GISTs. About 80 percent of cases are associated with a mutation in the KIT gene, and about 10 percent of cases are associated with a mutation in the PDGFRA gene. Mutations in the KIT and PDGFRA genes are associated with both familial and sporadic GISTs. Less than 10 percent of cases are SDH-deficient GISTs, which are associated with mutations or other changes in the SDHA, SDHB, SDHC, or SDHD gene. SDH-deficient GIST can be familial or sporadic. A small number of people with a GIST have mutations in other genes.
Approximately 5,000 new cases of GIST are diagnosed in the United States each year. SDH-deficient GIST accounts for about 5 to 7 percent of cases. However, GISTs may be more common than the estimate because small tumors may remain undiagnosed.
Most cases of GIST are sporadic and are not inherited. These cases are associated with a somatic mutation, which is a genetic change that occurs only in the tumor cells and occurs during a person's lifetime.
Brigham And Women's Hospital, Division Of Surgical Oncology
Dr. Raut is the Chief of the Division of Surgical Oncology and the inaugural Distinguished Chair for Cancer Care at Brigham and Women's Hospital. He received a BA and BS from Stanford University, MSc from University of Oxford, and MD from Harvard Medical School, where he is also a Professor of Surgery. He completed his residency in general surgery at Massachusetts General Hospital and fellowship in surgical oncology at MD Anderson Cancer Center. Dr. Raut specializes in the multidisciplinary care of patients with soft tissue sarcoma and serves as the Surgery Director for the Center for Sarcoma and Bone Oncology at Dana-Farber Brigham Cancer Center (DFBCC). His research focuses on multimodal strategies to reduce rates of local recurrence for patients with sarcoma. Dr. Raut is rated as an Elite provider by MediFind in the treatment of Gastrointestinal Stromal Tumor. He is also highly rated in 28 other conditions, according to our data. His clinical expertise encompasses Adult Soft Tissue Sarcoma, Gastrointestinal Stromal Tumor, Liposarcoma, Nephrectomy, and Pancreaticoduodenectomy. Dr. Raut is board certified in Surgery, General.
Duke Cancer Center
I am a medical oncologist who focuses on bone and soft tissue cancers called sarcomas. I love spending time with my patients. They often have a sense of awareness about their condition that’s truly unique and rewarding. I partner with each patient so they know the full set of options available for treatment and can make an informed decision about the approach that is best for them. I’ve wanted to pursue medicine for as long as I can remember. I find cancer fascinating because of its ability to evade the immune system. The body fails to recognize cancer as being foreign. When I am not at work, I love spending time with my family and enjoy long distance running. Dr. Riedel is rated as an Elite provider by MediFind in the treatment of Gastrointestinal Stromal Tumor. He is also highly rated in 30 other conditions, according to our data. His clinical expertise encompasses Adult Soft Tissue Sarcoma, Liposarcoma, Desmoid Tumor, and Angiosarcoma. Dr. Riedel is board certified in American Board Of Internal Med, Internal Medicine and American Board Of Internal Med, Medical Oncology.
Penn Endocrine And Oncologic Surgery Radnor
Ronald Dematteo is a General Surgeon practicing medicine in Radnor, Pennsylvania. Dr. Dematteo is rated as an Elite provider by MediFind in the treatment of Gastrointestinal Stromal Tumor. He is also highly rated in 24 other conditions, according to our data. His clinical expertise encompasses Gastrointestinal Stromal Tumor, Cholangiocarcinoma (Bile Duct Cancer), Pancreatic Cancer, Hepatectomy, and Pancreatectomy. Dr. Dematteo is board certified in Surgery, 1998. Dr. Dematteo is currently accepting new patients.
Summary: Gastrointestinal stromal tumors (GISTs) are the most common submucosal tumors (SMTs) of the stomach. The 2022 European Society of Oncology ESMO Diagnosis and Treatment Guidelines recommend that GISTs undergo biopsy with a clear pathological diagnosis and should be removed unless there are significant complications. But currently, the diagnostic rate of EUS-FNA for upper gastrointestinal subcutaneo...
Objective: To follow people with GISTs and collect tumor tissue so that it can be studied in the lab.
Published Date: July 14, 2021
Published By: National Institutes of Health